| 杜豆1 彭军1 李智信1 罗文伟1 任建强1 王启林2.结肠直肠腺瘤和结肠直肠腺癌组织中STAT3，Bcl-2 和MMP-2
的表达及意义[J].现代生物医学进展英文版,2014,14(36):7114-7117. |
| 结肠直肠腺瘤和结肠直肠腺癌组织中STAT3，Bcl-2 和MMP-2
的表达及意义 |
| The Expressions and Clinical Significance of STAT3, Bcl-2, and MMP2 inColorectal Adenomas and Adenocarcinomas |
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| DOI： |
| 中文关键词: 结肠直肠腺瘤 结肠直肠腺癌 信号转导和转录活化因子3 原癌基因蛋白质c-bcl-2 基质金属蛋白酶 病理学 |
| 英文关键词: Colorectal adenoma Colonic adenocarcinoma of rectum Signal transduction and activation of transcription factor 3 Proto oncogene proteins c-bcl-2 Matrix metalloproteinase Pathology |
| 基金项目:云南省教育厅科学研究基金项目(2012Z07) |
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| 中文摘要: |
| 目的：探讨信号转导和转录活化因子3 (signal transducer and activator of transcription 3,STAT3)，Bcl-2 和基质金属蛋白酶
(matrix metalloproteinase，MMP-2) 在结肠直肠腺瘤和结肠直肠腺癌中的表达，研究其与结肠直肠腺癌临床病理特征和预后的关
系，阐明三者在结肠直肠腺癌的浸润转移、判断预后中的作用。方法：选取我院2011 年9 月至2013 年8 月结直肠黏膜慢性炎100
例，结肠直肠腺瘤100 例，结肠直肠腺癌200 例石蜡标本，其中结肠直肠腺癌伴远处转移70 例，无远处转移130 例，采用Envison
二步法检测STAT3，Bcl-2和MMP-2 在三种组织中的表达。结果：STAT3，Bcl-2 和MMP-2在结肠直肠腺瘤、腺癌的阳性表达率明
显高于在结直肠黏膜慢性炎中的阳性表达率，差异有统计学意义(P<0.05)；STAT3、MMP-2在结肠直肠腺癌伴有远处转移病例的
阳性表达率明显高于没有远处转移的病例，差异有统计学意义(P<0.05)；Bcl-2在结肠直肠腺癌伴有远处转移病例的阳性表达率与
没有远处转移病例的阳性表达率差异无统计学意义(P>0.05)。结论：STAT3，Bcl-2 和MMP-2均与结肠直肠癌的发生，发展有关；
STAT3 和MMP-2与结肠直肠癌的远处转移相关，可能提示患者预后不良，可作为评价结肠直肠腺癌复发与转移、不良生存预后
的候选临床标志。 |
| 英文摘要: |
| Objective:To investigate the expressions of signal transducer and activator of transcription factor3 (STAT3), Bcl-2,
and matrix metalloproteinase 2 (MMP-2) in colorectal adenomas and adenocarcinomas, and to explore the relationship with the colorectal
clinicopathological features and prognosis of intestinal adenocarcinomas, and their roles in the invasion, metastasis and the prognosis of a
colorectal cancer.Methods:The samples were selected from our hospital from September 2011 to August 2013, including 100 cases of
paraffin-coded colorectal mucosas with chronic inflammation, 100 cases of paraffincoded colorectal adenoma and 200 cases of
paraffin-coded colorectal adenocarcinomas (70 cases with metastasis and 130 cases without distant metastasis). Envison two-step method
was used to detect the expressions of STAT3, Bcl-2, and MMP-2 in each sample.Results:The expression of STAT3, Bcl-2, and MMP-2
in colorectal adenomas and adenocarcinomas were significantly higher than those in colorectal mucosas with chronic inflammation (P<0.
05). The expressions of STAT3 and MMP-2 in colorectal adenocarcinomas with distant metastasis were significantly higher than those
without distant metastasis (P<0.05). No significant difference of Bcl-2 expression was observed in colorectal adenocarcinomas with and
without distant metastasis (P>0.05).Conclusion:STAT3, Bcl-2 and MMP-2 were associated with the occurrence and development of
colorectal carcinoma. STAT3 was associated with the distant metastasis of colorectal carcinoma and might indicate a poor prognosis.
STAT3 might be used as a candidate clinical sign for the recurrence, metastasis, andpoor survival prognosisof colorectal adenocarcinoma. |
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