| 陈坚1 肖吓鹏1 陈先达1 李翰城1 王长淼.胆石患者术后胆盐转运子BSEP、MRP2、NTCP的水平变化及意义[J].现代生物医学进展英文版,2014,14(36):7083-7086. |
| 胆石患者术后胆盐转运子BSEP、MRP2、NTCP的水平变化及意义 |
| Expression and Significance of Bile Salt Transporter Factors BSEP, MRP2,NTCP in Patients with Gallbladder Stone after Laparoscopic JointCholedochoscope Surgery |
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| DOI： |
| 中文关键词: 腹腔镜 胆道镜 胆囊结石 胆盐转运因子 |
| 英文关键词: Laparoscopic Choledochoscope Gallbladder stones Bile salts transporter factors |
| 基金项目:国家自然科学基金项目(81273922) |
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| 中文摘要: |
| 目的：探讨腹腔镜联合胆道镜微创手术对胆囊结石患者胆盐转运因子胆盐输出泵（BSEP）、多重耐药蛋白2（MRP2）和牛黄
胆酸钠转运蛋白（NTCP）水平的影响。方法：选取我院普外科收治的胆囊结石患者20 例排除手术和麻醉禁忌症，予腹腔镜联合胆
道镜微创手术治疗。治疗结束后，对比治疗前后患者BSEP、MRP2、NTCP水平变化。结果：①治疗后患者肝脏组织中BSEP、MRP2
水平明显比治疗前升高，差异有统计学意义（P＜0.05）；②治疗后患者肝组织中NTCP 水平与治疗前水平无明显变化，差异无统计
学意义（P＞0.05）。结论：腹腔镜联合胆道镜微创手术治疗胆囊结石能升高患者胆盐转运因子BSEP、MRP2 水平，提高患者术后对
胆盐的转运和胆汁酸的代谢，降低胆囊结石复发率，对临床具有指导意义，值得临床推广。 |
| 英文摘要: |
| Objective:To investigate the change of bile salt transporter factors bile salt export pump (BSEP), multiple
drug-resistant proteins 2 (MRP2) and cow bile acid sodium transporters (NTCP) levels in patients with gallbladder stone after
laparoscopic joint choledochoscope minimally invasive surgery.Methods:20 patients with gallbladder stones without surgery and
anesthesia contraindications were selected fromdepartment of general surgery. Then the joint choledochoscope to laparoscopic minimally
invasive surgery was performed. The change of BSEP, MRP2, NTCP levels in liver tissues of patients was detected and compared before
and after treatment.Results:(1) After treatment, the transcript and protein level of BSEP, MRP2 was significantly higher than before
treatment, the difference was statistically significant (P < 0.05); (2) Before and after treatment, no obvious change in NTCP mRNA level
was detected (P>0.05).Conclusion:Laparoscopic joint choledochoscope minimally invasive surgery can increase bile salt transfer factors
BSEP, MRP2 level in patients with gallbladder stone, improve postoperative transport of bile salt and metabolism of bile acid, and reduce
the recurrence rate of gall bladder calculi, which is worthy of clinical promotion. |
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