| 华佳1 王凉1 张悦1 张秋花1 李深2.缬沙坦对高血压合并肾小球肾炎患者Scr 和GFR 水平的影响[J].现代生物医学进展英文版,2014,14(36):7070-7072. |
| 缬沙坦对高血压合并肾小球肾炎患者Scr 和GFR 水平的影响 |
| Effect of Valsartan on the Level of Scr and GFR in Patients of High BloodPressure with Glomerular Nephritis |
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| DOI： |
| 中文关键词: 缬沙坦 高血压 肾小球肾炎 Scr GFR |
| 英文关键词: Valsartan High blood pressure Glomerulonephritis Scr GFR |
| 基金项目:国家自然科学基金重点项目（30330710） |
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| 中文摘要: |
| 目的：探讨缬沙坦治疗高血压并肾小球肾炎临床疗效及对Scr（血清肌酐）、GFR（肾小球滤过率）水平变化的影响及临床意
义。方法：选取我院收治的126 例高血压合并肾小球肾炎患者为研究对象，随机分成A、B 两组，各63 例。A 组给予低剂量（80
mg/d）缬沙坦，B 组给予高剂量（160 mg/d）缬沙坦。记录两组患者治疗前后SBP，Scr，GFR 等临床指标变化情况及不良反应。结果：
治疗前两组各项指标对比无明显差异（P>0.05）；治疗后，A，B 两组SBP 均较治疗前显著下降（P<0.05）；A 组Scr 呈升高趋势（P<0.
05），B 组Scr 呈轻微下降趋势（P>0.05）；A组、B 组GFR变化不明显（P>0.05）。A 组不良反应率为4.76% ，B 组为9.52%，差异不
显著（P>0.05）。结论：对高血压合并肾小球肾炎患者给予高剂量缬沙坦，降压效果及耐受性好，毒副作用低，患者血清肌酐及肾小
球虑过率水平无明显变化，值得临床推广。 |
| 英文摘要: |
| Objective:To explore the clinical curative effect of valsartan in pateients of high blood pressure with glomerular
nephritis and its effects on the level change of Scr and GFR.Methods:126 cases of hypertension with glomerularnephritisin our hospital
were selected as the research objects, which were randomly divided into A, B groups with number table method, each group with 63
cases, under valsartantherapy, in which group A was given low doses (80mg/d) and group B was given high doses (160mg/d). The change
of the two groups before and after treatment of patients with various clinical indicators was recorded, and the adverse reaction was
observed.Results:Before the treatment, no difference between the two groups of indicators before treatment (P>0.05). After treatment of
valsartan, SBP in the control group and observation group significantly decreased than before treatment (P<0.05). Scr in group A showed
an increase trend (P<0.05), while in group B, Scr A slight declined (P>0.05). No significant change of GFR was detected in group A and
groupB (P>0.05). Adverse reaction rate of group A was 4.76%, while it was 9.52%in group B, without significant difference between
them(P>0.05).Conclusion:High dose of valsartanin patients with hypertension combined glomerulonephritis has antihypertensive effect
and good tolerance, low toxic and side effect, and the patients' serumcreatinine and glomerular rate has no obvious change after drug, so
it is worthy of clinical popularization and application to alleviate the illness. |
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