| 吕云利1 赵波1 姚向荣1 廖军1 刘超2 曾乐平2△.癫痫症患者脑细胞线粒体代谢功能研究[J].现代生物医学进展英文版,2014,14(36):7056-7059. |
| 癫痫症患者脑细胞线粒体代谢功能研究 |
| Study on the Metabolismof Brain Cells Mitochondria Functionin Epilepsy Patients |
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| DOI： |
| 中文关键词: 癫痫 GABA NAA 微量渗析 |
| 英文关键词: Epilepsy GABA NAA Microdialysis |
| 基金项目:国家自然科学基金项目（81100663） |
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| 中文摘要: |
| 目的：探讨人类大脑中主要的抑制性神经递质GABA（酌-氨基丁酸）对癫痫患者大脑代谢的作用。方法：二组接受癫痫部位
颅内监测的患者：手术治疗的海马区癫痫症患者（MTLE）和新皮质区（非海马区癫痫）癫痫症患者。在颅内监测过程中使用体内微
量透析法监测胞外GABA（ecGABA）。术前使用体内核磁共振成像技术检测N- 乙酰天冬氨酸（NAA）与肌酸（NAA/Cr）的比例。
使用标准方法进行神经病理学和海马体积检测。结果：在新皮质区组的海马区内，ecGABA 的升高与NAA/Cr 的升高相关（R =+0.
70，P<0.015，n=12），而在MTLE组的海马区中，ecGABA 的升高是由NAA/Cr的下降所引起的（R = 0.94，P<0.001，n=8）。在MTLE
组，ecGABA 的升高和NAA/Cr 的降低皆与神经胶质细胞数的增多有关（分别为R = +0.71, P<0.01，n=12 和R = 0.76，P<0.03）。二
组中ecGABA 的浓度和海马体积均没有明显的相关性。结论：在癫痫症中，ecGABA 的升高是由一系列的代谢功能变化引起的。
在癫痫部位以外，ecGABA和NAA/Cr同步升高；而在癫痫部位，线粒体功能的下降却伴随着ecGABA 的升高。 |
| 英文摘要: |
| Objective:To investigate the inhibitory neurotransmitter GABA mainly in the human brain (GABA) on cerebral
metabolismin patients with epilepsy. Methods:2 groups of patients with epilepsy received intracranial monitoring: operation treatment of
hippocampal epilepsy (MTLE) and cortex (non hippocampal epilepsy) in patients with epilepsy. In vivo microdialysis monitoring of
extracellular GABA (ecGABA) was applied in the process of intracranial monitoring. In vivo nuclear magnetic resonance imaging
technique was used for the detection of N- acetyl aspartic acid(NAA) and creatinine(NAA/Cr) ratio. While standard method was used to
detect neuropathology and hippocampal volume.Results:In the group of new cortex hippocampus, the evaluation of NAA/Cr was
associated with that of ecGABA(R =+0.70, P<0.015, namely, n=12), while in group MTLE of the hippocampus, the increase of ecGABA
was caused by the decrease of NAA/Cr (R= 0.94, P<0.001, n=8). In MTLE group, both the evaluation of ecGABA and the reduction of
NAA/Cr were related to the increase of glial cell number(R's +0.71=P<0.01, namely, n=12 and R's = 0.76, P<0.03). The concentration of
EcGABA had no obvious correlation with hippocampal volume in either group.Conclusion:In epilepsy, the increase of ecGABA is
caused by a change in a series of metabolic function. In epilepsy outside the site, ecGABA and NAA/Cr synchronously increase; and in
epilepsy parts, decrease of mitochondrial function is accompanied by the increase of ecGABA. |
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