| 周钰娟1，2 廖前进1 罗玉平3 许金华2 秦振启2 张秋菊2△ 何国平.金樱子提取液对糖尿病肾病大鼠的肾脏保护作用[J].现代生物医学进展英文版,2014,14(36):7019-7024. |
| 金樱子提取液对糖尿病肾病大鼠的肾脏保护作用 |
| Renal Protective Effect of Extracts from Rosa LaevigataMickx.on DiabeticNephropathy Rats |
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| DOI： |
| 中文关键词: 金樱子 糖尿病肾病 肾功能 肾脏病理 |
| 英文关键词: Rosa LaevigataMickx Diabetic nephropathy Renalfunction Renal pathology |
| 基金项目:湖南省自然科学基金项目（13JJ4077）；湖南省科技厅课题（2010FJ6025） |
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| 中文摘要: |
| 目的：研究金樱子提取液对糖尿病肾病（Diabetic Nephropathy，DN）大鼠的肾脏保护作用。方法：在高糖高脂饲料喂食SD
（Sprague-Dawley）大白鼠的基础上腹腔注射链脲佐菌素（streptozotocin，STZ）诱导糖尿病肾病大鼠模型，随机分为糖尿病肾病模
型组（DN 组）和金樱子治疗组（DN+RLM 组），同时另设正常对照组（NC 组）和金樱子对照组（NC+RLM 组）。检测金樱子提取液
对各组大鼠血糖（fasting blood-glucose，FBG）、糖化血红蛋白（glycosylated haemoglobin，GHb）、24 小时尿微量白蛋白和尿量、血尿
素氮（BUN）、血肌酐（Scr）、胆固醇（TC）、甘油三酯（TG）及肾脏结构的影响。结果：与DN大鼠相比，糖尿病肾病大鼠经金樱子提取
液治疗后，大鼠FBG、GHb 水平、24 h尿微量白蛋白、24 h尿量、肾脏指数明显降低，血脂紊乱、肾功能损害以及DN肾脏病理明显
改善，且无明显副作用。结论：金樱子提取液可明显降低DN大鼠血糖，改善DN 大鼠血脂、肾功能紊乱及肾脏病理变化，对糖尿病
大鼠肾脏具有较强的保护作用。 |
| 英文摘要: |
| Objective:To investigate the renal protective effect of extracts from Rosa LaevigataMickx (RLM) on diabetic
nephropathy rats.Methods:After fed with a high-fat/high-sucrose/high-cholesterol diet, SD rats were administered STZ in a single dose
of 65mg/kg intraperitoneally (i.p.) to establish the diabetic nephropathy model, and then the diabetic nephropathy rats were randomly
selected and divided into two groups as follows: Diabetic nephropathy model group (DN), Diabetic nephropathy + Rosa LaevigataMickx.
group (DN + RLM, fed with extracts of RLM, 5 g/kg/d). And normal SD rats were into divided two groups as follows: normal control
group (NC), and normal control + Rosa LaevigataMichx. group (NC + RLM, fed with extracts of RLM, 5 g/kg/d). The fasting
blood-glucose(FBG), glycosylated haemoglobin(GHb), urine microalbumin and urinevolume in 24 h, blood urea nitrogen(BUN), serum
creatinine(Scr), total cholesterol(TC), triglyceride(TG) and the renal pathology change were measured in every group.Results:Compared
with the DN group, diabetic nephropathy rats which were treated with extracts of RLM, the disorder of FBG, GHb, urine microalbumin
and urine volume in 24h, dyslipidemia, renal dysfunction and the renal pathologicalchange were significantly ameliorated, and there was
no noticeable side effects of RLMon the rats.Conclusion:RLMis able to ameliorate the disorder of plasma blood glucose, dyslipidemia,
renal dysfunction and renal pathologicalchange, and has obvious renal protective effect on diabetic nephropathy rats. |
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