| 黄琳琳 张学鹏 白勇 袁万博 张金梅△.磁性纳米技术在癌症基因治疗中的应用[J].现代生物医学进展英文版,2014,14(35):6990-6992. |
| 磁性纳米技术在癌症基因治疗中的应用 |
| The Application of Magnetic Nanoparticle Technology in CancerGene Therapy |
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| DOI： |
| 中文关键词: 磁性纳米技术 基因治疗 靶向 癌症 传递方法 |
| 英文关键词: Magnetic nanoparticle technology Gene Therapy Targeting Cancer Delivery method |
| 基金项目:湖北省科技厅软科学研究专项计划（2011DEA031） |
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| 中文摘要: |
| 癌症基因组的最新进展使直接针对癌症基因进行治疗具有极大的可能性。然而，需要新的基因传递方法使这种潜力向临床
应用转化，为治疗病人服务。磁性纳米技术是通过外部磁场选择性地高效传递治疗基因，还能同时用影像监测体内的传递过程。
相比传统的基因传递方法，这种技术能明显提高人类移植肿瘤和不同的内脏器官如肝、肾及中枢神经系统的基因传递效率。因
此，磁性纳米技术使活体内癌症的基因治疗进入到新的前沿领域。 |
| 英文摘要: |
| Recent advances in cancer genomics have opened up unlimited potential for treating cancer by directly targeting
culprit genes. However, novel delivery methods are needed in order for this potential to be translated into clinically viable treatments for
patients. Magnetic nanoparticle technology offers the potential to achieve selective and efficient delivery of therapeutic genes by using
external magnetic fields, and also allows simultaneous imaging to monitor the delivery in vivo. Compared to conventional gene delivery
strategies, this technique has been shown to significantly increase gene delivery to human xenograft tumors models, as well as various
internal organs (e.g. liver, kidney) and the central nervous system. Magnetic nanoparticle technology, therefore, has the potential to turn
the challenge of gene therapy in vivo into a new frontier for cancer treatment. |
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