| 安凌王 陈艳 隋丽娟 贾丽梅 孙秀芹.臭氧自血疗法及其在糖尿病治疗中的应用[J].现代生物医学进展英文版,2014,14(35):6984-6987. |
| 臭氧自血疗法及其在糖尿病治疗中的应用 |
| Ozonated Autohemotherapy and Its Use in Diabetes Treatment |
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| DOI： |
| 中文关键词: 氧化应激 抗氧化剂 糖尿病 臭氧自血疗法 |
| 英文关键词: Oxidative stress Antioxidants Diabetes Ozone autohemotherapy |
| 基金项目: |
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| 中文摘要: |
| ：目前，糖尿病及其并发症已经成为我国一个重大的公共卫生问题。大量研究证实，氧化应激与糖尿病大血管和微血管并发
症的发生及发展密切相关。臭氧自血疗法的应用已有半个世纪，低强度、精确计算且可重复的臭氧自血治疗可诱发标准化的急性
氧化应激，使机体的抗氧化防御系统得到锻炼和增强，而在此过程中产生的一定数量的信使，可以与血液和实质细胞产生相互作
用，改善缺血组织的血液循环和氧供，使免疫系统轻度活化，增加生长因子的释放，激活神经保护系统，改善患者的健康状态。虽
然有证据显示臭氧治疗在改善血糖和血脂控制方面的贡献，且安全性良好，但迄今为止，臭氧自血疗法的临床试验数据还相当欠
缺，有必要开展设计良好的临床试验，进行长期观察，以获得其应用和推广所需的更为确凿的证据。本综述旨在探讨臭氧自血疗
法的作用机制及应用前景。 |
| 英文摘要: |
| Currently, diabetes and its complications has become a major public health problem in China. Numerous studies
demonstrated that oxidative stress is closely related to the occurrence and development of macrovascular and microvascular
complications. Ozone autohemotherapy has been used for almost half a century. A "physiological", low intensity, precisely and
repeatably calculated ozone autohemotherapy can induce standardized acute oxidative stress, which can enhance the body 's antioxidant
defense system. A number of messengers generated in this process can interact with blood cells and substances, improve the blood
circulation and oxygen delivery in ischemic tissue, induce a mild activation of the immune system, increase the release of growth factors,
activate the neuroprotective system, and procure a surprising wellness in most patients. Although there is evidence that ozone therapy
contributs to the improvement of glycemic and lipid control with fascinating safety, but so far, the clinical trials of ozone
autohemotherapy are still quite lacking. Well-designed long-term clinical trials are necessary to obtain more conclusive evidence for its
application and promotion. The mechanisms of action of ozone autohemotherapy are reviewed in this paper. The perspective of its use is
also mentioned. |
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