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目的：通过观察 PQ 中毒患者 SOD、TNF-琢、IL-6、PaO2、 PaCO2、 BUN 和 Cr 水平，及血浆 PQ 浓度的变化，旨在探讨大黄在治疗 PQ 中毒中的作用。方法： 36 例急性百草枯中毒患者随机分为对照组(n=15)和治疗组(n=21)，所有患者均给予常规治疗，对照组应用甘露醇导泻，治疗组应用生大黄混悬液导泻，采用酶联免疫吸附法(enzyme linked immunosorbent assay， ELISA)检测所有患者血清 SOD、TNF-琢、 IL-6 水平，高效液相色谱法(High Performance Liquid Chromatography， HPLC)测定患者血浆 PQ 浓度，并测定 PaO2、 PaCO2、 BUN 和 Cr。结果：治疗组患者第 1、3、 7 天 PaO2、SOD 水平显著高于对照组， PaCO2、 BUN、Cr、 TNF-琢、IL-6 水平和 PQ 浓度亦较对照组均显著降低(P<0.05)。结论：大黄可降低 PQ 中毒患者血中 PQ 浓度，抑制 TNF-琢、 IL-6 的表达，明显升高 SOD 的水平，改善 PQ 中毒患者肺、肾功能。

英文摘要:

Objective:To study the effects and protecting mechanism ofRhubarb by observing the changes ofSerum SOD, TNF-琢, IL-6, PaO2, PaCO2, BUN and Cr levels and plasma paraquat concentration in patients with paraquat poisoning.Methods:36 patients with paraquat poisoning were randomly divided into control group (n=21 ) and treatment group (n=15). Both groups were treated with conventional therapy. The control group were treated with mannitol for catharsis, and the treatment group with rhubarb suspension. Serum SOD, TNF- 琢, IL-6 were measured by ELISA, and the plasma concentration of paraquat were measured by HPLC, and determined PaO2, PaCO2, BUN and Cr.Results:PaO2, SOD on 1, 3, 7 days of patients in the treatment group were significantly higher than that of the control group, and PaCO2, BUN, Cr, TNF-琢, IL-6 level, the concentration of paraquat was significantly lower than the control group (P<0.05).Conclusion:Rhubarb can reduce the concentration of paraquat, inhibit exrpression of serum TNF-琢, IL-6, and SOD levels rised in patients with paraquat poisoning. Furthermore, Rhubarb can improve the lung function andkidney function in patients with paraquat poisoning.

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