| 刘凌燕 栾希英 陈小涛 周立芳.麻醉剂七氟烷与地氟烷对患者中性粒细胞和 T 细胞的影响研究[J].现代生物医学进展英文版,2014,14(35):6904-6908. |
| 麻醉剂七氟烷与地氟烷对患者中性粒细胞和 T 细胞的影响研究 |
| Effects of Sevoflurane and Desflurane on Neutrophils and T Cells ofPatients |
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| DOI： |
| 中文关键词: 麻醉 地氟烷 七氟烷 |
| 英文关键词: Anesthesia Desflurane Sevoflurane |
| 基金项目:教育部新教师基金项目（ 201001621 20072） |
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| 中文摘要: |
| 目 的： 探讨腹腔手术过程中七氟烷与 地氟烷麻醉对患者中性粒细胞和 T 细胞的影响。 方法： 随机选取 85 例年龄在 20-60 岁
的患者，将患者随机分成二组， 分别使用 七氟烷与 地氟烷进行麻醉。在麻醉前 30 min 和麻醉后 2-24 h 分别检测患者白细胞、淋巴
细胞、中性粒细胞的数量、 T 辅助淋巴细胞（ CD4）、细胞毒性 T 淋巴细胞（ CD8）、自 然杀伤性淋巴细胞、激活 T 淋巴细胞的百分比，
CD4/CD8 的比值， 血浆皮质醇含量。 结果： 二组患者白细胞与 中性粒细胞麻醉 24 h 后显著升高（ P<0.01）。 地氟烷组中性粒细胞数
量显著高于七氟烷组（ P<0.05）。 CD4 细胞的百分比在七氟烷组中无显著改变，在麻醉后 2h， 地氟烷组（ 31.93%[6.65%]）同 基础值
（ 36.41 % [6.92%]）相比显著降低（ P<0.05）， 24 h 后进一步下降（ 30.52%[8.01 %]）（ P<0.01）。 七氟烷组 CD4/CD8 比值一直无变化，但
地氟烷组在麻醉 2 h 降低（ 1 .51 [0.52]）， 24 h 明显升高（ 1.82[0.72]）（ P<0.05）。 结论： 与 地氟烷相比， 七氟烷对中性粒细胞群与 T 细
胞群的影响较小。 |
| 英文摘要: |
| Objective:To observe effects of sevoflurane and desflurane anesthesia on immune function in patients with
abdominal operation.Methods:The subjects were 85 adult patients aged between 20 and 60 (the association of anaesthetists American
physiological state is I or II). They were randomly divided into two groups, given sevoflurane and desflurane anesthesia respectively. At
30 min before anesthesia and 2-24 hours after anesthesia, we detected the white blood cells, lymphocytes, the number of neutrophils, T
helper lymphocytes (CD4), cytotoxic T lymphocyte (CD8), the percentage of natural killer cells, activation of Tlymphocytes, CD4/CD8
ratio, and the content of plasma cortisol.Results:There was significant increase in the white blood cells and neutrophils at 24 hours after
anesthesia (P<0.01) in the two groups. In desflurane group, the number of neutrophils was significantly higher than that of sevoflurane
group (P<0.05). The percentage of CD4 cells had no significant change in the sevoflurane group, but significantly decreased in desflurane
group (P<0.05) 2h after anesthesia (31 .93%[6.65%]) as compared with the baseline value (36.41 %[6.92%]), and further declined (30.52%
[8.01 %]) (P<0.01 ) 24 h after anesthesia. The CD4/CD8 ratio showed no change yet in sevoflurane group, but declined at 2 h(1 .51 [0.52] )
yet increased at 24 h in the desflurane group (1.82[0.72]) (P<0.05).Conclusion:Compared with desflurane, sevoflurane has lesser effect
on neutrophilgroup and T cell populations. |
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