| 陈明辉 李瑞岩 冯 岩 蒿忠飞 赵哲峰 孙 旭 李永利.MTHFR 基因多态性与中国北方人群脑膜瘤发病的相关性分析[J].现代生物医学进展英文版,2014,14(35):6827-6829. |
| MTHFR 基因多态性与中国北方人群脑膜瘤发病的相关性分析 |
| Correlative Analysis of MTHFR Gene Polymorphism with the Incidence ofMeningioma in Population of North China |
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| DOI： |
| 中文关键词: 亚甲基四氢叶酸还原酶 脑膜瘤 多态性 关联性 |
| 英文关键词: MTHFR Meningioma Polymorphism Association |
| 基金项目:黑龙江省青年科学基金项目（ QC2014C108） |
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| 中文摘要: |
| 目 的： 探讨亚甲 基四氢叶酸还原酶(MTHFR)基因 多态性与 中 国 北方人群脑膜瘤发病的 相关性。 方法： 选择 2012 年 1 月
-2013 年 12 月 在黑龙江省哈尔滨医科大学附属第 二医院的第 一、三病房接受手术治疗的脑膜瘤患者 317 例 (实验组)及 320 例 非
脑膜瘤患者（对照组）为研究对象， 利 用 聚合酶链反应限制性多态性片段长度(PCR-RFLP)检测和比较两组 MTHFR 两个单核苷酸
多态性位点(C677T、 A1298C)各种基因型(CC、 CT、 TT)的分布情况及等位基因的频率。 结果： 两组 MTHFR 的 C677T 中 CC 基因型
的频率和 TT 基因型的频率比较有显著性差异 (CC： OR=2.012， 95%CI=1 .460-2.772； TT： OR=0.399， 95%CI=0.254-0.628， P＜ 0.05)，
实验组 MTHFR 的 (0.450)C677T 中的 T 等位基因 频率明 显高于对照组 (0.320)(OR=0.529， 95%CI=0.420-0.666， P＜ 0.05)。 两组
A1298C 的等位基因 分布比较没有统计学差别 (P＞ 0.05)。 结论： MTHFR 基因的 C677T 中 TT 等位基因 提示潜在的易患脑膜瘤的
风险， 而 CC 等位基因 会降低中国北方人群患脑膜瘤的风险。 |
| 英文摘要: |
| Objective:To explore the correlation of gene polymorphism of msethylene tetrahydrofolate reductase (MTHFR) with
the incidence of meningiomain in a Han population of north China.Methods:A total of 317 cases of meningioma patients (experimental
group) and 320 cases of non-meningioma patients (control group) were enrolled in this case-control study. The patients who underwent
surgery were recruited from the First and Third Ward of Neurosurgery of the Second Af覱liated Hospital of Harbin Medical University,
Heilongjiang Province, North of China from January 2012 to December 2013. The distribution of different genetypes (CC, CT, TT) and
allele frequencies of two SNPs (C677T and A1298C) of MTHFR were detected and compared between two groups using polymerase
chain reaction restriction fragment length polymorphism (PCR-RFLP).Results:There were statistically signi覱cant differences in the CC
and TT (CC: OR=2.012, 95% CI=1 .460-2.772; TT: OR=0.399, 95% CI=0.254-0.628, P<0.05) frequencies of MTHFR C677T between
two groups (P<0.05). The T allele frequency of MTHFR C677T of experimental group (0.450) was significantly higher than that of the
control group (0.320) (OR=0.529, 95% CI=0.420-0.666, P<0.05). No statistically signi 覱cant difference was observed in the allele
distribution of A1298C between two groups (P>0.05).Conclusion:TT genotype of MTHFR C677T indicated a potential risk of
meningioma, while the decrease of CC alleles of C677T reduced the risk of meningioma in a Han population in northern China. |
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