| 严伟红 孙成晖 李艺 罗庆芬 罗向卫.非小细胞肺癌患者血清淀粉样蛋白A 水平与放射性肺炎的相关性研究[J].现代生物医学进展英文版,2014,14(34):6719-6722. |
| 非小细胞肺癌患者血清淀粉样蛋白A 水平与放射性肺炎的相关性研究 |
| Study of Correlation Between SerumAmyloid A Level and RadiationPneumonitis in Patients with Non-Small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 非小细胞肺癌 放射性肺炎 血清淀粉样蛋白A |
| 英文关键词: Non-small cell lung cancer Radiation pneumonitis Serumamyloid A |
| 基金项目:阳春市科技发展项目（2514411） |
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| 中文摘要: |
| 目的：评估非小细胞肺癌患者血清淀粉样蛋白A（SAA）水平与发生放射性肺炎（RP）的相关性。方法：选取我院确诊为非小
细胞肺进行肺部病灶放射治疗的患者118 例，评价是否发生放射性肺炎,并在放疗前及放疗剂量达到43 GY 时分别抽取患者血
清样本，应用酶联免疫法（ELISA）检测患者血清淀粉样蛋白A含量。结果：43 例患者发生了放射性肺炎，发生放射性肺炎组患者
的放疗前血清淀粉样蛋白A 水平明显高于未发生放射性肺炎组，两组对比，差异有统计学意义（P<0.05）。而在放疗剂量达到43
Gy时，发生放射性肺炎组患者的血清淀粉样蛋白A水平与未发生放射性肺炎组患者相比，差别无统计学意义。结论：对于非小细
胞肺癌患者，通过检测放疗前血清淀粉样蛋白A 水平可以预测放射性肺炎的发生。 |
| 英文摘要: |
| Objective:The purpose of this study is to evaluate the correlation between serum amyloid A level and radiation
pneumonitis in patients with non-small cell lung cancer.Methods:118 cases of non-small cell lung cancer patients treated with
radiotherapy in our hospital were collected and diagnosed with radiation pneumonitis. The serum amyloid A level of the patients were
measured through using enzyme linked immunosorbent assay (ELISA) before radiation therapy and at the dose of 43 Gy.Results:43 out
of 118 patients developed radiation pneumonitis, and the serum amyloid A level before radiation therapy in radiation pneumonitis group
was significantly higher than that in non-radiation pneumonitis group(P<0.05). There was no significant difference between the Radiation
pneumonitis group and non-radiation pneumonitis group in the serum amyloid A level at the dose of 43 Gy.Conclusion:Measuring the
serumamyloid A level before radiation could predict the happening of radiation pneumonitis in patients with non-small cell lung cancer. |
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