石瑞雪 吕坤聚 张柯晴 高伟.CREB 和CXCR2 在非小细胞肺癌组织中的表达及意义[J].现代生物医学进展英文版,2014,14(34):6714-6718. |
CREB 和CXCR2 在非小细胞肺癌组织中的表达及意义 |
The Expression and Significance of CREB and CXCR2 in NSCLC |
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DOI: |
中文关键词: 肺肿瘤 CREB CXCR2 免疫组织化学 趋化因子 |
英文关键词: Lung neoplasm CREB CXCR2 Immunohistochemistry Chemokine |
基金项目:全军科研课题(06Z013) |
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中文摘要: |
目的:探讨cAMP 反应原件结合蛋白(cyclic AMP response element-binding protein,CREB)和CXC 趋化因子受体2(CXC
chemokine receptor 2,CXCR2)在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及与肺癌发生、发展的关系。方
法:采用免疫组化Elivision 法检测CREB 和CXCR2 在49 例NSCLC组织中的表达,同时随机选取20 例癌旁正常肺组织作为对
照。结果:NSCLC 中CREB 和CXCR2 的表达阳性率分别为57.1 %和69.4 %,均显著高于癌旁正常组织中的10.0 %和15.0%
(P<0.05);同时,CREB 和CXCR2 在NSCLC组织中的表达不仅与肿瘤的TNM 分期有关(P<0.05),而且还与肿瘤的分化程度
有关(P<0.05);另外,CREB 在吸烟患者中的表达明显高于非吸烟患者(P<0.05),在鳞癌组织中的表达明显高于腺癌(P<0.05);
CREB 和CXCR2 的表达呈正相关。结论:CREB 和CXCR2 可能参与了NSCLC的发生和发展,为NSCLC 的靶向治疗提供了新
的依据。 |
英文摘要: |
Objective:To investigate the protein expression of cyclic AMP response element-binding protein (CREB) and CXC
chemokine receptor 2 (CXCR2) in non-small cell lung cancer (NSCLC) in order to investigate their relationship with clinical and
pathological features of NSCLC patients.Methods:The immunohistochemical Elivision method was used to detect the expression of
CREB and CXCR2 in NSCLC tissue(n=49) and adjacent normal lung tissue(n=20).Results:High expression of CREB and CXCR2 was
observed in 57.1%and 69.4%of NSCLC tissue and 10%and 15%of adjacent normal lung tissue (P<0.05). The expression of CREB
and CXCR2 was related to both tumor stages and cell differentiation in NSCLC (P<0.05). CREB expression was obviously higher in
both squamous cell carcinoma and the smokings than that in adenocarcinoma and non-smokings (P<0.05), whereas CXCR2 in both
histologic subtype and Smoking status was less or not affected by them (P>0.05). CREB expression was demonstrated to associate
positively with CXCR2.Conclusion:CREB and CXCR2 may play a vital synergetic role in the progress of NSCLC because of
overexpression in NSCLC tissue, which may provide a potential therapeutic target for the prevention and treatment of NSCLC. |
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