| 喻青 沈曼茹 唐鄂 黄继英 高振军.CK-18 降解片段M30和MMP-2 在慢性乙型肝炎纤维化严重程度
预测中的作用[J].现代生物医学进展英文版,2014,14(34):6650-6653. |
| CK-18 降解片段M30和MMP-2 在慢性乙型肝炎纤维化严重程度
预测中的作用 |
| The Predictive Effect of SerumApoptotic Cytokeratin 18 Neoepitope M30(CK-18 M30) and Matrix Metalloproteinase 2 (MMP-2) Levels inHBeAg-negative Chronic Hepatitis B Patients with Fibrosis |
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| DOI： |
| 中文关键词: 慢性乙型肝炎 细胞角蛋白-18 基质金属蛋白酶 肝纤维化 |
| 英文关键词: Chronic hepatitis B Cytokeratine 18 neoepitope M30 Matrix metalloproteinase 2 Liver fibrosis |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血清细胞角蛋白-18 裂解片段M30(CK-18 M30)和基质金属蛋白酶(MMP-2)水平对乙型肝炎e 抗原（HBeAg）阴
性慢性乙型肝炎纤维化严重程度预测的作用。方法：选取我院156 例HBeAg 阴性的慢性乙型肝炎（CHB）患者和51 例对照组。肝
组织病理学分级依据Scheuer标准。常规收集临床资料，ELISA 法检测血清CK-18 M30和MMP-2 水平。结果：本研究CHB组男
性为106 人（67.9%），女性为50人（32.1%）；对照组男性为33 人（63.5%），女性为19 人（36.5%），两组间性别、年龄无统计学差异；
CHB组CK-18 M30和MMP-2 显著高于对照组（P<0.001）。CK-18 M30 预测是否有显著性肝纤维化的AUC为0.863（P<0.001）；
而MMP-2 预测是否有显著性肝纤维化的AUC为0.587，差异无统计学意义（P=0.064）。结论：血清CK-18 M30 和MMP-2 水平在
CHB组显著升高，CK-18 M30 可能可预测HBeAg 阴性的慢性乙型肝炎纤维化严重程度，可能具有较好的临床应用前景。 |
| 英文摘要: |
| Objective:The objective of this study was to investigate the significance of cytokeratine 18 neoepitope M30 (CK-18
M30) and matrix metalloproteinase 2 (MMP-2) levels for patients with chronic hepatitisB (CHB) and fibrosis.Methods:This study
included 156 CHB patients and 52 healthy controls. Scheuer scoring system was used to determine the fibrosis level in chronic hepatitis
B patients. CK-18 M30 and MMP-2 levels were measured using Enzyme Linked Immunosorbent Assay (ELISA) methods.Results:The
CHB group consisted of 106 (67.9%) males and 50 (32.1%) females, and the control group consisted of 33 males (63.5%) and 19 females
(36.5%). In our study, the areas under the ROC curve (AUCs) of CK-18 M30 and MMP-2 for predicting significant fibrosis were 0.863
（P<0.001）and 0.587（P=0.064）, respectively.Conclusion:We found that CK-18 M30 and MMP-2 levels were higher in CHB patients
compared to healthy controls. CK-18 M30 may predict HBeAg-negative chronic hepatitis B patients with significant fibrosis, and the
application of the marker is promising. |
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