| 杨改红 任刚 肖锡林 黄群 余日跃 杨武亮 陈海芳 袁金斌.代谢组学在中药研究中的应用进展[J].现代生物医学进展英文版,2014,14(33):6582-6585. |
| 代谢组学在中药研究中的应用进展 |
| Progress of Metabonomics in TCMResearch |
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| DOI： |
| 中文关键词: 代谢组学 中药研究 研究进展 |
| 英文关键词: Metabonomics Traditional Chinese medicine Progress |
| 基金项目:国家自然科学基金项目（81060326, 31200140）；江西省教育厅科研项目（GJJ09277） |
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| 中文摘要: |
| 代谢组学是功能基因组学和系统生物学研究不可或缺的重要组成部分，是通过考察生物体系受刺激或扰动前后代谢产物
的动态变化，研究生物体系的代谢网络的一种技术。应用代谢组学高通量、整体性的研究思路来理解中药的作用过程，与中医药
的整体、辩证观点是一致的。代谢组学已成为中药研发的一个重要途径和手段，为中药现代化在技术上提供巨大支持，有助于为
中药现代化研究寻找更多有效的突破口。本文在前人综述的基础上，着重概括了中药代谢组学研究方法近3 年来在中药有效物
质基础和作用机制、药物作用模型的鉴别和确证、毒性研究和中药安全性评价等方面的应用情况，同时展望了代谢组学方法所面
临的机遇和挑战。 |
| 英文摘要: |
| Metabonomics is an indispensable important constituent of functional genomics and systems biology research, and a
kind of technology which focuses on the metabolic network of biosystem by investigating dynamic changes of the metabolites in the
biological organism after the stimulation and disturbance. Metabonomics take an organic conception of the human body, which conforms
to the way of thinking of traditional Chinese medicine ( TCM). Metabonomics have become an important way and means in the research
and development of traditional Chinese medicine, provided great technique support for the modernization of TCM, and could help to find
more effective breakthrough for TCM modernization. Based on the previous reviews, this paper reviews the research progresses during
the recent 3 years in the following fields such as material basis, mechanism of action, the identification and confirmation of the drug
action model, toxicity research and the safety evaluation of TCM, and analyzes the future opportunities and challenges that would be
confronted during the motabonomics research . |
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