| 张磊 朱一辰 张超 张健 解泽林.群体反应性抗体对再次肾移植患者的影响研究[J].现代生物医学进展英文版,2014,14(33):6496-6498. |
| 群体反应性抗体对再次肾移植患者的影响研究 |
| Correlation Study of Panel Reaction Antibody and the SecondRenal Transplantation |
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| DOI： |
| 中文关键词: 再次肾移植 群体反应性抗体（PRA） 肾功能 |
| 英文关键词: Second renal transplantation Panel reaction antibody Renal function |
| 基金项目: |
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| 中文摘要: |
| 目的：研究群体反应性抗体（PRA）对再次肾移植患者移植肾长期存活和肾功能的影响。方法：采用美国GTI 公司提供的
ELISA 筛选HLA-I类、Ⅱ类混合抗原板，对59 例再次肾移植患者进行PRA 检测。鉴定抗体类型采用美国One lanmbda 公司鉴定
抗原板(LAT.1240)。同时检测移植肾功能。结果：59 例再次肾移植患者中，抗体阳性患者16例，占27.12%（16/59），其中抗HLA-I
类抗体3 例，占5.08%（3/59），抗HLA-II类抗体9 例，占15.25%（9/59），抗HLA-I+II类抗体4 例,占6.78%(4/59)。抗体阳性与抗体
阴性患者比较，肾功能下降或丧失具有显著性差异（x2=33.634, P<0.001）。结论：抗HLA 抗体阳性是影响再次肾移植患者移植肾长
期存活的重要因素。 |
| 英文摘要: |
| Objective:To study the influence of the panel reaction antibody on the survival of the renal transplantation and renal
function of patients of second renal transplantation.Methods:PRA expressions in 59 cases of the second renal transplantation patients
were examined using the enzyme linked Immunosorbent HLA-I, HLA-II hybrid screening antigen plate provided by the United States
GTI company(LAT.1240), the renal function was also examined.Results:In 59 cases of second renal retransplantation patients, there were
16 cases of antibody positive patients, accounting for 27.12% (16/59), including 3 cases of anti HLA-I antibody, accounting for 5.08%
(3/59), 9 cases of anti HLA-II antibody, accounting for 15.25% (9/59) and 4 cases of anti HLA-I+II antibody, accounting for 6.78%
(4/59). To compare the renal function decline or loss in patients of antibody positive and antibody negative, there was significant
difference (x2=33.634, P<0.001).Conclusion:The anti HLA antibody is an important factor affecting the long-term survival of the second
renal transplantation. |
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