| 张凯 张立婷 鲁明霞 王霏霏 陈红.病毒性肝病抗病毒治疗期间新发肝癌7 例临床分析[J].现代生物医学进展英文版,2014,14(33):6493-6495. |
| 病毒性肝病抗病毒治疗期间新发肝癌7 例临床分析 |
| Clinical Analysis of 7 Cases of Viral Liver Disease Related HepatocellularCarcinoma during Antiviral Treatment |
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| DOI： |
| 中文关键词: 原发性肝癌 抗病毒 治疗 病毒性肝炎 肝硬化 |
| 英文关键词: Hepatocellular carcinoma Antiviral Treatment Viral hepatitis Cirrhosis |
| 基金项目:国家“十一五”重大专项(2008ZX1002-013) |
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| 中文摘要: |
| 目的：探讨病毒性肝炎肝硬化患者经抗病毒治疗仍发生原发性肝癌的原因。方法：回顾性分析兰州大学第一医院东岗院区
肝病中心在2012 年10 月-2013 年6 月收治的7 例病毒性肝炎肝硬化患者在规范抗病毒治疗期间新发原发性肝癌的临床资料、
抗病毒治疗情况。结果：7 例患者中有HBV 感染6例，HCV 感染1 例；慢性肝炎2 例，肝硬化5 例；HBeAg 阴性5 例；3 例合并糖
尿病；经抗病毒治疗后病毒载量均处于低度复制或不可测状态。结论：病毒性肝炎肝硬化患者经抗病毒治疗不能完全消除原发性
肝癌发生的风险,病毒载量、HBeAg 阴性、糖尿病、肝硬化等可能是肝癌发生的危险因素。 |
| 英文摘要: |
| Objective:To explore the cause of viral liver disease related hepatocellular carcinoma during antiviral treatment.Methods:A retrospective study from October 2012 to June 2013 in Liver Disease Center of Dong Gang District Affiliated to the First
Hospital of Lanzhou University was preformed. Clinical data of 7 cases that viral liver disease patients arising hepatocellular carcinoma
during standard antiviral treatment were analyzed.Results:7 patients with HBV infection in 6 cases, HCV infection in 1 case. 2 cases
underwent chronic hepatitis, 5 cases underwent liver cirrhosis. HBeAg negativity in 5 cases. 3 patients had diabetes. All viral replication
was low or no after antiviral therapy.Conclusion:Suppression of viral replication in viral liver disease patients does not completely
eliminate the risk of hepatocellular carcinoma. Viral load, HBeAg negativity, diabetes, cirrhosis may be risk factors of hepatocellular
carcinoma. |
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