司慧远 靳雁斌 李晓娟 张宏伟 周平.抗病毒治疗乙型肝炎相关慢加急性肝衰竭患者的临床研究[J].现代生物医学进展英文版,2014,14(33):6464-6466. |
抗病毒治疗乙型肝炎相关慢加急性肝衰竭患者的临床研究 |
Clinical Studies on Anti-viral Therapy for the Hepatitis B Patients with Acuteon Chronic Liver Failure |
|
DOI: |
中文关键词: 乙型肝炎相关慢加急性肝衰竭 乙型肝炎病毒 拉米夫定 恩替卡韦 |
英文关键词: Hepatitis B combined with acute on chronic liver failure Hepatitis B virus Lamivudine Entecavir |
基金项目: |
|
Hits: 692 |
Download times: 798 |
中文摘要: |
目的:探讨抗病毒治疗乙型肝炎相关慢加急性肝衰竭(acute on chronic liver failure,ACLF)的临床意义。方法:回顾性分析
2007 年8月~2013年8 月我院收治的乙型肝炎相关慢加急性肝衰竭的住院患者80 例,按照患者有无接受抗病毒治疗分为抗病
毒治疗组(A 组)50 例和未抗病毒治疗组(B 组)30 例,分析患者接受治疗后的近期与远期疗效、并发症及生存率。结果:①出院时
A 组好转率70%;B 组好转率33.3%。两组比较差异有统计学意义(x2=10.243,P=0.001<0.05)。②治疗14 周后A 组乙肝病毒
DNA阴转率72%;B组阴转率30%,两组比较差异有统计学意义(x2=13.440,P=0.000<0.05)。③A 组出现细菌感染45例,电解质
紊乱41 例,消化道出血5 例,肝性脑病10 例,肝肾综合征10 例,B组出现细菌感染30 例,电解质紊乱27 例,消化道出血6 例,肝
性脑病10 例,肝肾综合征12 例,两组比较差异无统计学意义(x2=2.755,P=0.097>0.05)。④随访5 年,A 组存活36 例,死亡14
例,12、36 和60 个月累积生存率分别为78.5%、71.2%、71.2%,B 组存活5 例,死亡25 例,12、36 和60 个月累积生存率分别为
35.4%、27.5%、27.5%,两组比较差异有统计学意义(P<0.05)。结论:对乙型肝炎相关慢加急性肝衰竭患者给予抗病毒治疗可明显
改善预后,提高生存率。 |
英文摘要: |
Objective:To explore the clinical significance of anti-viral therapy for the hepatitis B patients with acute on chronic
liver failure.Methods:80 cases of hepatitis B patients with acute on chronic liver failure in our hospital from August 2007 to August
2013 were selected for retrospective analysis, and were divided into antiviral treatment group (group A of 50 cases) and
non-antiretroviral treatment group (group B of 30 cases). Recent and long-term efficacy, complications and survival rates and other
indicators were analyzed after treatment.Results:① The improvement rate of Group A was 70%, while 33.3% for Group B ,the
difference was statistically significant (x2 = 10.243, P= 0.001<0.05). ② The HBV DNA negative rate of group A after 14 weeks of
treatment was 72%, while 30%for Group B, the difference was statistically significant (x2= 13.440, P=0.000<0.05). ③ In group A, there
were 45 cases of bacterial infection, 41 cases of electrolyte disorder, 5 cases of gastrointestinal bleeding in, 10 cases of hepatic
encephalopathy, while group B had 10 cases of hepatorenal syndrome, 30 cases of bacterial infections, 27 cases of electrolyte disorder, 6
cases of gastrointestinal bleeding, 10 cases of hepatic encephalopathy, and 12 cases of hepatorenal syndrome, the difference was not
statistically significant (x2= 2.755, P= 0.097 > 0.05). ④ Follow-up of 5 years showed that 36 cases survived in group A while 14 cases
died, the cumulative survival rates at 12, 36 and 60 months were 78.5%, 71.2%, and 71.2%respectively; There were 5 cases of surviving
in group B and 25 cases of death, the cumulative survival rates at 12, 36 and 60 month was 35.4%, 27.5%, and 27.5%, the difference was
statistically significant (P<0.05).Conclusion:Anti-viral therapy can significantly improve the prognosis and survival rate in hepatitis B
patients with acute on chronic liver failure. |
View Full Text
View/Add Comment Download reader |
Close |
|
|
|