Article Summary
司慧远 靳雁斌 李晓娟 张宏伟 周平.抗病毒治疗乙型肝炎相关慢加急性肝衰竭患者的临床研究[J].现代生物医学进展英文版,2014,14(33):6464-6466.
抗病毒治疗乙型肝炎相关慢加急性肝衰竭患者的临床研究
Clinical Studies on Anti-viral Therapy for the Hepatitis B Patients with Acuteon Chronic Liver Failure
  
DOI:
中文关键词: 乙型肝炎相关慢加急性肝衰竭  乙型肝炎病毒  拉米夫定  恩替卡韦
英文关键词: Hepatitis B combined with acute on chronic liver failure  Hepatitis B virus  Lamivudine  Entecavir
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Author NameAffiliation
SI Hui-yuan, JIN Yan-bin, LI Xiao-juan, ZHANG Hong-ei, ZHOU Ping 空军总医院医院感染内科空军总医院神经内科 
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中文摘要:
      目的:探讨抗病毒治疗乙型肝炎相关慢加急性肝衰竭(acute on chronic liver failure,ACLF)的临床意义。方法:回顾性分析 2007 年8月~2013年8 月我院收治的乙型肝炎相关慢加急性肝衰竭的住院患者80 例,按照患者有无接受抗病毒治疗分为抗病 毒治疗组(A 组)50 例和未抗病毒治疗组(B 组)30 例,分析患者接受治疗后的近期与远期疗效、并发症及生存率。结果:①出院时 A 组好转率70%;B 组好转率33.3%。两组比较差异有统计学意义(x2=10.243,P=0.001<0.05)。②治疗14 周后A 组乙肝病毒 DNA阴转率72%;B组阴转率30%,两组比较差异有统计学意义(x2=13.440,P=0.000<0.05)。③A 组出现细菌感染45例,电解质 紊乱41 例,消化道出血5 例,肝性脑病10 例,肝肾综合征10 例,B组出现细菌感染30 例,电解质紊乱27 例,消化道出血6 例,肝 性脑病10 例,肝肾综合征12 例,两组比较差异无统计学意义(x2=2.755,P=0.097>0.05)。④随访5 年,A 组存活36 例,死亡14 例,12、36 和60 个月累积生存率分别为78.5%、71.2%、71.2%,B 组存活5 例,死亡25 例,12、36 和60 个月累积生存率分别为 35.4%、27.5%、27.5%,两组比较差异有统计学意义(P<0.05)。结论:对乙型肝炎相关慢加急性肝衰竭患者给予抗病毒治疗可明显 改善预后,提高生存率。
英文摘要:
      Objective:To explore the clinical significance of anti-viral therapy for the hepatitis B patients with acute on chronic liver failure.Methods:80 cases of hepatitis B patients with acute on chronic liver failure in our hospital from August 2007 to August 2013 were selected for retrospective analysis, and were divided into antiviral treatment group (group A of 50 cases) and non-antiretroviral treatment group (group B of 30 cases). Recent and long-term efficacy, complications and survival rates and other indicators were analyzed after treatment.Results:① The improvement rate of Group A was 70%, while 33.3% for Group B ,the difference was statistically significant (x2 = 10.243, P= 0.001<0.05). ② The HBV DNA negative rate of group A after 14 weeks of treatment was 72%, while 30%for Group B, the difference was statistically significant (x2= 13.440, P=0.000<0.05). ③ In group A, there were 45 cases of bacterial infection, 41 cases of electrolyte disorder, 5 cases of gastrointestinal bleeding in, 10 cases of hepatic encephalopathy, while group B had 10 cases of hepatorenal syndrome, 30 cases of bacterial infections, 27 cases of electrolyte disorder, 6 cases of gastrointestinal bleeding, 10 cases of hepatic encephalopathy, and 12 cases of hepatorenal syndrome, the difference was not statistically significant (x2= 2.755, P= 0.097 > 0.05). ④ Follow-up of 5 years showed that 36 cases survived in group A while 14 cases died, the cumulative survival rates at 12, 36 and 60 months were 78.5%, 71.2%, and 71.2%respectively; There were 5 cases of surviving in group B and 25 cases of death, the cumulative survival rates at 12, 36 and 60 month was 35.4%, 27.5%, and 27.5%, the difference was statistically significant (P<0.05).Conclusion:Anti-viral therapy can significantly improve the prognosis and survival rate in hepatitis B patients with acute on chronic liver failure.
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