欢迎访问《现代生物医学进展》编辑部！

目的：探讨载脂蛋白亚型与糖尿病合并冠脉病变严重程度相关性，为预防及治疗糖尿病伴发的动脉粥样硬化性疾病提供新的依据。方法：选取440 名心内科患者，根据冠脉造影有无冠脉狭窄及是否合并糖尿病分为四组：冠脉内膜光滑组94 人（A组）；单纯冠脉狭窄组108 人（B 组）；糖尿病合并冠脉狭窄组共184 人（C 组）；糖尿病冠脉无狭窄组44 人（D 组），记录患者空腹血糖、餐后血糖、传统血脂脂谱、载脂蛋白A（apoA）、载脂蛋白B(apoB)及两者的比值(apoB/apoA)；采用Gensini 评分比较传统血脂、apoA、 apoB 及与Gensini积分值的相关性。结果：与正常对照组比较，糖尿病冠脉无狭窄组apoB、apoB/apoA、LDL和TG升高，apoA和 HDL降低，B 组和C 组apoA与Gensini积分值存在负相关（P=0.0157<0.05）；apoB；apoB/apoA 与Gensini 积分值存在正相关(P<0. 0001)；两组中，apoB与Gensini 积分值相关系数最大（r=0.85795，0.85941），且apoB 与Gensini 积分值的相关性都强于LDL 与积分值的相关性。结论：在糖尿病患者预测心血管风险上，apoB, apoA，apoB/apoA 的测定可能优于传统的血脂指标。

英文摘要:

Objective:To investigate the relationship between the apolipoprotein isoforms and severity of diabetes with coronary heart disease, and to provide new evidences for early diagnosis and prevention of diabetes combined with coronary atherosclerosis.Methods:440 patients from department of cardiology were selected and randomly divided into four groups according to the coronary angiography with and without coronary artery stenosis and whether combined with diabetes mellitus: A group (normal control group, n= 94), B group (coronary heart disease, n=108), C group (coronary heart disease with diabetes mellitus, n=184). D group (diabetes mellitus without coronary heart disease, n=44). Fasting blood glucose, postprandial blood glucose, apoB, apoA, apoB/apoA ratio were measured. The degree of coronary stenosis was evaluated by calculating Gensini's score. The correlation between the Gensini's score and the level of apoA, apoB and apoA/apoB was compared.Results:Compared with coronary heart disease combined type 2 diabetes group, ApoAand Gensini score value was negatively related. ApoB level and apoB/apoAratio were positively correlated with Gensini score value. Comparing coronary heart disease combined type 2 diabetes group with simple stenosis of coronary disease groups and type 2 diabetes without coronary heart disease, ApoB with Gensini score value correlation coefficient (r = 0.85795, 0.85941), the largest and the correlation between apoB and Gensini score value was stronger than LDL and the integral value of correlation.Conclusion:On the prediction of cardiovascular risk in diabetes patients, apoB, apoA, and apoB/apoA determination may be superior to the traditional lipid indexes.

View Full Text View/Add Comment Download reader