| 杭振宁 童超 徐斌 王士琪 白槟 赵青川.E-cadherin 在胃癌术后复发预测中的临床意义[J].现代生物医学进展英文版,2014,14(32):6260-6264. |
| E-cadherin 在胃癌术后复发预测中的临床意义 |
| The Clinical Significance of E-cadherin in Predicting the Recurrence ofGastric Cancer after Curative Resection |
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| DOI： |
| 中文关键词: E-cadherin 胃癌 复发 预后 |
| 英文关键词: E-cadherin Gastric cancer Recurrence Prognosis |
| 基金项目:国家自然科学基金项目(81370564) |
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| 中文摘要: |
| 目的：探讨E-cadherin 在胃癌术后复发预测中的临床意义。方法：选择我院2006 年1月至2010 年7 月收治的胃癌或者胃食
管连接部癌行胃癌根治性切除术后259 例患者为研究对象，将其分为术后复发组(115 例)和术后未复发组(144 例)，采用免疫组织
化学方法检测其E-cadherin 的表达，并分析E-cadherin 的异常表达与胃癌术后复发的相关性。结果：胃癌癌旁正常组织与胃癌组
织间E-cadherin 的表达有显著差异(P<0.05)；胃癌术后复发与未复发患者的胃癌组织E-cadherin 的表达比较有显著差异(P<0.05)。
E-cadherin 的异常表达与胃癌的浸润深度、淋巴结转移和TNM 分期显著相关(P<0.05)。单因素Logistic 回归分析发现，E-cadherin
的异常表达的与胃癌术后复发有显著的相关性(P=0.039，RR=1.711，95%Cl为1.486-1.970)。结论：E-cadherin的异常表达与胃癌根
治性切除术后复发显著相关。 |
| 英文摘要: |
| Objective:To study the clinical significance of E-cadherin in predicting the recurrence of gastric cancer after curative
resection.Methods:We studied 259 patients, including 115 patients inrecurrent group and 144 patients in non-recurrent group, who
suffered gastric or gastroesophageal junction cancer after radical resection in our hospital fromJanuary 2006 to July 2010, the expression
of E-cadherin in gastric cancer patients with recurrence and non-recurrence after radical resectionby were detected by
immunohistochemistry and the correlation between abnormal expression of E-cadherin and gastric cancer recurrencewere analyzed.Results:There were significant differences of E-cadherin expression between normal gastric tissues and gastric cancer tissues (P<0.05);
the E-cadherin expression of gastric cancer tissues of recurrent and non-recurrent patients with gastric cancer after surgery also had
significant differences (P<0.05). Abnormal E-cadherin expression was significantly associated with the depth of invasion, lymph node
metastasis and TNM staging of patients with gastric cancer (P<0.05); Univariate Logistic regression analysis showed that abnormal
expression of E-cadherinwas correlated with the recurrence of gastric cancer after surgery (P=0.039, RR=1.711, 95% Cl=1.486-1.970).Conclusion:The abnormal expression of E-cadherin may be associated with the recurrence of gastric cancer after curative resection. |
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