| 支磊 赵明佐 冷君志 董理 王琦.TACE与手术治疗原发性大肝癌的临床疗效比较[J].现代生物医学进展英文版,2014,14(31):6148-6150. |
| TACE与手术治疗原发性大肝癌的临床疗效比较 |
| Comparison of the Therapeutic Effect of TACE and Operation in theTreatment of Patients with Primary Large Hepatocellular Carcinoma |
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| DOI： |
| 中文关键词: 经导管肝动脉化疗栓塞 原发性大肝癌 手术 临床疗效 |
| 英文关键词: Transcatheter arterial chemoembolization(TACE) Primary Large hepatocellular carcinoma Operation Clinical efficacy |
| 基金项目:国家自然科学基金项目(81101873)；宁夏自然科学基金项目(NZ10153) |
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| 中文摘要: |
| 目的：比较经导管肝动脉化疗栓塞(transcatheter arterial chemoembolization，TACE)和手术治疗原发性大肝癌(肿瘤最大直
径≥ 5 cm)的临床疗效和安全性。方法：回顾性分析48 例经TACE 或手术(Operation)治疗的原发性大肝癌患者，其中TACE 组25
例，Operation 组23 例，治疗后随访24 个月，评价和比较其治疗效果、生存曲线、镇痛剂的日平均用量及不良反应的发生情况。结
果：治疗后3 个月，TACE 组患者的Karnofsky评分(P=0.033)显著高于Operation组，而血清甲胎蛋白(AFP)水平(P=0.022)显著低于
Operation 组。此外，TACE 组的镇痛药杜冷丁的日均使用量显著低于Operation 组(P=0.031)，便秘的日均发生次数(P=0.045)显著
少于Operation 组。治疗后24 个月，TACE 组和Operation 组的生存率分别为48.0 %和17.4 %，TACE 组显著高于Operation 组
(P=0.0415，95%CI of ratio: 1.006 to 1.994)。结论：TACE 治疗原发性大肝癌的临床疗效可能优于手术治疗，且安全性高。 |
| 英文摘要: |
| Objective:To compare the therapeutic effect and safety of transcatheter arterial chemoembolization (TACE) and
operation in the treatment of patients with large hepatocellular carcinoma (the maximumdiameter of tumor≥ 5 cm).Methods:48 cases of
large hepatocellular carcinoma were retrospectively investigated, in which 25 cases were treated with TACE, and 23 cases were treated
with operation. After 24-month's follow-up, the effectiveness, survival curves, average daily dose of analgesics and side effects were
compared between the two groups.Results:Three months after the treatment, the Karnofsy score of TACE group was significantly higher
than that of the operation group (P=0.033), but the AFP level was obviously lower than that of the operation group (P=0.022). In addition,
the daily dose of analgesic dolantin (P=0.031) and incidence of coprostasis (P=0.045) of TACE group were lower than those of the
operation group. After 24-month's follow-up, the survival rates of TACE group and operation group were 48.0 % and 17.4 %
respectively, and the survival rate of TACE group was significantly higher than that of the operation group (P=0.0415, 95 %CI of ratio:
1.006 to 1.994).Conclusion:The effectiveness and safety of TACE may be better than those of operation in the treatment of large
hepatocellular carcinoma. |
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