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目的：评估非变应性鼻炎（nonallergic rhinitis, NAR）患者全身、鼻腔及下气道嗜酸性粒细胞（Eosinophils，EOS）浸润水平及相关性。探讨EOS在NAR 患者鼻腔及下气道的特征及意义。方法：2011 年6 月～2012 年6 月在我院就诊的NAR 患者241 例，同期征集健康对照组222 例，所有受试者均进行病史采集、皮肤点刺实验（SPT）、血清嗜酸性粒细胞、鼻灌洗、诱导痰检查。结果：① NAR组和对照组相比鼻灌洗EOS 计数、诱导痰EOS 比例、血EOS 比例均显著高于健康对照组（P均＜0.01）。② 有鼻腔EOS 炎症和无鼻腔EOS炎症层的诱导痰EOS 百分比阳性率分别为34.7%vs 9.6%（P＜0.01）。③NAR组鼻灌洗EOS计数和诱导痰EOS 比例存在明显相关性（r=0.262, P=0.000），鼻灌洗EOS 计数和血EOS 比例存在明显相关性（r=0.228, P=0.000），诱导痰EOS 比例和血EOS 比例存在明显相关性（r=0.291, P=0.000）。结论：NAR 患者血液、鼻腔及下气道EOS 浸润程度较正常对照组均明显升高， EOS 在NAR患者血液、鼻腔及下气道炎症中存在明显一致性，提示NAR 是一种全身系统性炎症性疾病；无下气道症状的NAR 患者部分存在下气道EOS炎症，鼻腔及血液EOS炎症是导致下气道EOS 炎症的主要高危因素。鼻灌洗EOS 可能是观测NAR 患者下气道炎症及对下气道炎症进行评估和追踪的有效指标。EOS 可能是鼻炎、哮喘及血液炎症相关的效应细胞，是上下气道炎症有效生物标记物。

英文摘要:

Objective:To evaluate the infiltration degree and correlation of Eosinophils (EOS) inflammation in systemic, upper and lower airway in patients with nonallergic rhinitis (NAR), approaching the characteristics and significance about EOS in NAR.Methods:This paper assessed 241 patients with nonallergic rhinitis and 222 health adults, by using disease survey, skin prick test (SPT), nasal douche, serum eosinophil, and induced sputum respectively in all subjects.Results:① The eosinophil in nasal douche, induced sputumand serumin NAR group were significantly higher than that in control group (P<0.01); ②The positive rate of eosinophil in nasal douche for the nasal cavity with and without EOS inflammation was the 34.7% vs 9.6%(P＜0.01); ③ There was obvious correlation between the eosinophil in nasal douche and induced sputum (r=0.262, P=0.000), between the eosinophil in nasal douche and serum (r=0. 228, P=0.000), between the induced sputum and serum (r=0.291, P=0.000).Conclusion:NAR was a systematic inflammation disease. Eosinophil played an important role among the connection of nasal cavity, lower airway and the whole body. Lower airway eosinophilsic inflammation developed despite the absence of lower airway symptoms in a proprotion of individuals with NAR. Nasal cavity and serum eosinophilsic inflammation were the major risk factors for lower airway eosinophilsic inflammation. The nasal lavage EOS may be the indicators to observe lower airway inflammation in NAR patients. EOS may be the effector cells among rhinitis, asthma and systemic inflammation, as well as the upper and lower airway inflammation biomarkers.

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