| 徐燕霞 张鸿彦 张国利 赵文成 孙禄.原发性肾病综合征患儿尿蛋白转阴时间的影响因素分析[J].现代生物医学进展英文版,2014,14(31):6110-6113. |
| 原发性肾病综合征患儿尿蛋白转阴时间的影响因素分析 |
| Analysis of the Influencing Factors of Proteinuria Elimination Time inChildren with Primary Nephrotic Syndrome |
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| DOI： |
| 中文关键词: 儿童原发性肾病综合征 影响因素 logistic 回归分析 |
| 英文关键词: PNS Risk factors Regression |
| 基金项目:黑龙江省教育厅资助项目(11541182) |
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| 中文摘要: |
| 目的：探讨儿童原发性肾病综合征(primary nephrotic syndrome，PNS)经激素治疗后尿蛋白转阴时间的影响因素。方法：回顾
性分析68 例初发PNS 患儿的临床资料，通过激素治疗后，按照尿蛋白转阴时间进行分组，对患儿特征、化验指标进行单因素分析
和多因素非条件Logistic回归分析。结果：单因素分析显示水肿至口服激素时间、水肿程度、父母认知程度、有无合并感染、入院时
血浆IgM水平、白蛋白水平、胶体渗透压等指标在不同预后组间有显著性差异(P<0.05)。多因素分析显示水肿至口服激素时间长、
父母认知程度差、血浆胶体渗透压低可视为尿蛋白转阴时间大于1 周的危险因素。结论：水肿至口服激素时间长、父母认知程度
差、血浆胶体渗透压低为PNS患儿尿蛋白转阴时间长于1 周的危险因素，与患儿的不良预后相关，临床应予以高度重视。 |
| 英文摘要: |
| Objective:To analyze the influencing factors of proteinuria elimination time in children with primary nephritic
syndrome (PNS).Methods:68 cases of children with PNS were divided into two groups by proteinuria elimination tine after hormone
treatment. Children’s characteristics and laboratory indicators were collected, and then the univariate analysis and non-conditional
logistic regression analysis were performed.Results:according to the results of univariate analysis, the days of the oral steroid, edema,
parents' level of knowledge, with or without infection, admission plasma IgM levels, levels of albumin, and colloid osmotic pressure
showed significant difference in the prognosis between the groups, P<0.05. Multivariate analysis showed the longer days eating hormone
after edema, poor awareness level of parents, low plasma colloid osmotic pressure could be considered as risk factors for proteinuria
elimination for more than 1 week.Conclusion:Long time fromedema to the days of the oral steroid, bad parents' level of knowledge, low
colloid osmotic pressure are the risk factors of more than 1 week proteinuria elimination time of children with PNS, which are also related
to the worse prognosis and require more attention in clinc. |
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