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研究表明，喉癌的早期诊断、及时治疗不仅可以提高治愈率，而且也减少了患者的手术创伤和经济负担。积极开展喉癌的早期诊断研究具有重要的临床和社会意义。发现早期喉癌常规方法主要有电子喉镜、纤维喉镜、颈部CT 及MRI 检查，但并不能明显有效提高早期诊断率。而窄带成像（narrow band imaging，NBI）及自体荧光内镜(autofluorescence endoscopy AFE)是近几年用于喉癌早期诊断的两种新颖的内镜技术。NBI是一种通过变窄光波的波长，使粘膜上皮内乳头样毛细血管袢及粘膜下静脉的结构形成鲜明的对比，从而提高组织表面细微结构的对比度，便于发现病灶。而AFE 技术是一种利用自发荧光聚集于病变组织的某个区域产生的差异强度，来区别正常组织与肿瘤性病变，从而用于肿瘤的早期诊断及识别癌前病变。因此，对NBI及AFE 的进一步研究及认识对喉癌早期诊断提供非常重要的临床应用价值。

英文摘要:

Research shows that early diagnosis and timely treatment can not only improve the cure rate of laryngeal cancer, but also reduce the surgical trauma and economic burden of patients. Positive study on the early diagnosis of laryngeal cancer has important clinical and social significance. Conventional diagnosis method of early laryngeal cancerbasically includes electronic laryngoscope, fiber laryngoscope, neck CT and MRI, but does not significantly improve the early diagnostic rate. And narrow band imaging (narrow band imaging, NBI) and auto fluorescence endoscopy (auto fluorescence endoscopy AFE) are used for early diagnosis of laryngeal cancer in recent years, which are two novel endoscopic techniques. NBI is an imaging by narrowing the wavelength of light waves, making mucous membrane epithelial nipple sample in capillary loops and the structure of the submucosal veins in stark contrast, thus improving the surface microscopic structure of the tissue contrast, which makes it easy to find lesions. And AFE technology is a use of auto fluorescence gathered in a region of diseased tissue to produce differences in intensity, to distinguish between normal tissue and tumor lesions, thus for tumor early diagnosis and identification of precancerous lesions. Therefore, further study and understanding of NBI and AFE for laryngeal cancer early diagnosis can provide important clinical application value.

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