| 陈瑞芬 黄丽芳 曾建兵 邓常春 陈彩秀 李广华 姜孝新.血清镁、血小板聚集率在糖耐量减低患者微血管病变中的临床意义[J].现代生物医学进展英文版,2014,14(29):5723-5726. |
| 血清镁、血小板聚集率在糖耐量减低患者微血管病变中的临床意义 |
| The Clinical Meaning of the SerumMagnesiumLevel, Platelet AggregationRate in the Patients with Impaired Glucose Tolerance and Microangiopathy |
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| DOI： |
| 中文关键词: 糖耐量减低 微血管病变 血清镁 血小板聚集率 |
| 英文关键词: Impaired glucose tolerance Microangiopathy Serummagnesiumlevel Platelet aggregation rate |
| 基金项目:韶关市医药卫生科研计划项目(Y13043)；湖南省自然基金项目（14JJ2092） |
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| 中文摘要: |
| 目的：观察糖耐量减低患者微血管病变与血清镁、血小板聚集率(PAR)的相关性。方法：将2012 年11 月-2014 年1 月在本
院内分泌科和体检中心的120 例研究对象随机均分为糖耐量减低合并微血管病变组(n=30)，糖耐量减低无微血管病变组(n=30)，
糖尿病组(n=30)，正常对照组(n=30)。比较各组患者的生化指标、血清镁与PAR 的相关性、血镁水平以及PAR与FPG、HbA1C 相
关性。结果：糖尿病组和糖耐量减低合并微血管病变组患者的所有生化指标与对照组相比，差异有显著性(P<0.05)；血清镁水平与
PAR 之间呈显著负相关(P<0.01)；血镁水平与糖耐量减低合并微血管病变组、糖耐量减低无微血管病变组、糖尿病组中FPG、
HbA1C呈负相关关系(P<0.05)；PAR 与糖耐量减低合并微血管病变组、糖耐量减低无微血管病变组、糖尿病组中FPG、HbA1C 呈
正相关关系(P<0.05)。结论：血清镁与PAR在预测糖耐量患者微血管病变中有一定的临床意义，值得临床推广。 |
| 英文摘要: |
| Objective:To observe the relationship between the microangiopathy and serum magnesium level, platelet aggregation
rate of the patients with impaired glucose tolerance (IGT).Methods:120 cases from the department of endocrinology and medical
examination center were divided randomly into IGT with microangiopathy group (n=30), IGT without microangiopathy group (n=30),
diabetes mellitus(DM) group(n=30), and normal control group(n=30). The biochemical tests, correlation between the serum magnesium
and PAR, the correlation between the serum magnesium level and FPG, HbA1C and the correlation between PAR and FPG, HbA1C in
the four groups were compared.Results:Compared with the control group, statistical difference existed in all the biochemical tests of the
DMgroup and impaired glucose tolerance with microangiopathy group (P<0.05); and the serummagnesiumlevel was negative with PAR
(P<0.01). Furthermore, the serum magnesium level was negative with the FPG and HbA1C in the IGT with microangiopathy group, IGT
without microangiopathy group and DM group (P<0.05), but PAR was positive with the FPG and HbA1C in the IGT with
microangiopathy group, IGT without microangiopathy group and DM group (P<0.05).Conclusion:The serum magnesium and platelet
aggregation rate is conducive in predicting the microangiopathy for impaired glucose tolerance patients, and deserves wide application in
clinic. |
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