| 许杰阳 孙跃文 娄淼 刘竞辉 冯富强
冀培刚 李宝福 李毅 高国栋 王樑.尼莫司汀对复发恶性胶质瘤化疗的临床观察[J].现代生物医学进展英文版,2014,14(29):5720-5722. |
| 尼莫司汀对复发恶性胶质瘤化疗的临床观察 |
| Clinical Observation of Chemotherapy with ACNU in Recurrent Glioma |
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| DOI： |
| 中文关键词: 尼莫司汀 胶质瘤 复发 化疗 |
| 英文关键词: ACNU Glioma Recurrent Chemotherapy |
| 基金项目:卫生部医药科技发展计划研究课题（w2012fz104）；陕西省自然科学基金项目（2012JQ4003）；
吴阶平医学基金项目（320.6750.13332） |
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| 中文摘要: |
| 目的：探讨尼莫司汀在复发胶质瘤化疗的疗效。方法：回顾性分析接受尼莫司汀化疗的13 例复发胶质瘤患者的临床治疗效
果、生存时间及不良反应。结果：所有患者均接受超过3 个周期的化学治疗，平均完成4.6 个化疗周期。随访时间5-26 个月，平均
随访时间16 个月。3 个月无进展生存率53.8%；6 个月无进展生存率30.8%；12 月无进展生存率23.1%。2 例出现III度骨髓抑制，
其余不良反应包括恶心呕吐（6 例）和疲倦乏力（9 例），经积极治疗后均好转。结论：尼莫司汀为主的化疗方案是复发胶质瘤化疗
的有效手段之一，可以显著地延长患者的生命，并不伴有严重的并发症，特别是针对前期进行过TMZ 化疗的病例，具有价格低
廉，疗效相当的优点，是替莫唑胺治疗之外很好的选择。 |
| 英文摘要: |
| Objective:To investigate the effect of chemotherapy with ACNU on recurrent glioma.Methods:13 patients with
recurrent glioma treated with ACNU were retrospectivly analyzed for therapeutic effects, survival time and adverse reactions.Results:All
patients received more than three cycles of chemotherapy, with an average of 4.6 cycles. They were averagely followed-up for 16 months
(5-26 months). Progression-free survival rates of 3 months, 6 months and 12 months were 53.8%, 30.8% and 23.1%, respectively. Two
patients had bone marrow suppression during the course. The other adverse reactions included nausea and vomiting (6 cases) and fatigue
(9 cases), and improved after active treatment.Conclusion:Chemotherapy with ACNU is one of the effective methods for recurrent
glioma, which can significantly extend the lifetime of patients without serious complications. Patients who received TMZ-based
chemotherapy will benefit more fromACNU for its low price and comparable effect, thus, ACNU is a good choice for non-TMZ therapy. |
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