| 胡亚梅 李书剑 姜晓峰 李刚 张弥兰 张钱 林向莉.miR-146aC>G, miR-149 T>C 基因多态性与缺血性脑卒中易感性的研究[J].现代生物医学进展英文版,2014,14(29):5648-5650. |
| miR-146aC>G, miR-149 T>C 基因多态性与缺血性脑卒中易感性的研究 |
| Study on the Association of miR-146aC>G, miR-149 T>C Polymorphismwith Susceptibility to Ischemic Stroke |
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| DOI： |
| 中文关键词: 缺血性脑卒中 miR-146aC>G miR-149 T>C 易感性 |
| 英文关键词: Ischemic stroke MiR-146aC>G MiR-149 T>C Susceptibility |
| 基金项目:河南省科技厅重点科技攻关计划项目（122102310094） |
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| 中文摘要: |
| 目的：探讨中国汉族人群中miR-146aC>G，miR-149 T>C基因多态性与缺血性脑卒中易感性的关系。方法：利用聚合酶链式
反应- 限制性片段长度多态性（PCR-RFLP）的方法检测196 例缺血性脑卒中患者和205 例健康对照中miR-146aC>G，miR
-149T>C 的基因型，统计学方法比较两组间基因型及等位基因分布差异。结果：miR-146aC>G 位点各基因型在病例组和对照组分
布无明显差异，但等位基因G会增加缺血性脑卒中的患病风险；miR-149T>C 位点各基因型在病例组和对照组分布无明显差异。
在分层分析中，miR-146aC>G 会增加女性和非高血压患者缺血性脑卒中的患病风险，miR-149T>C 会增加非高血压患者缺血性脑
卒中的患病风险。结论：miR-146aG 等位基因，miR-149C 等位基因与汉族人群缺血性脑卒中易感性有一定的相关性。 |
| 英文摘要: |
| Objective:To investigate the relationship between miR-146aC>G, miR-149 T>C and susceptibility to ischemic stroke
in a Chinese population.Methods:Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) were used to
determine the genotype of 196 ischemic stroke patients and 205 healthy controls. Statistical analyses were used to compare the
distribution of the genotypes and alles between cases and controls.Results:There were no significant differences of the miR-146aC>G,
miR-149 T>C genotype between the cases and controls, but alle G of miR-146a can increase the risk of ischemic stroke. In the stratified
analyses, miR-146aCG+GG showed a significantly increased risk of ischemic stroke compared with the CC genotype of the female and
normotensive subgroups; miR-149TC+CC was connected to ischemic stroke in the normotensive subgroup.Conclusion:miR-146a alle
G, miR-149 alle C were associated with an increased risk of ischemic stroke in chinese. |
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