| 全昕 牛越 刘瑞峰 孙明丽 郭晓东.干扰素联合利巴韦林治疗慢性丙型肝炎的疗效及对肝功能和肝纤维化指标的影响[J].现代生物医学进展英文版,2014,14(28):5548-5551. |
| 干扰素联合利巴韦林治疗慢性丙型肝炎的疗效及对肝功能和肝纤维化指标的影响 |
| Clinical Effect of Interferon Combined with Ribavirin in Treating ChronicHepatitis C and its Effect on Liver Function and Liver Fibrosis Indexes |
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| DOI： |
| 中文关键词: 干扰素 利巴韦林 慢性丙型肝炎 肝功能 肝纤维化指标 |
| 英文关键词: Interferon Ribavirin Chronic hepatitis C Liver function Liver fibrosis |
| 基金项目:国家自然科学基金青年科学基金项目(30901795） |
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| 中文摘要: |
| 目的：探讨干扰素联合利巴韦林治疗慢性丙型肝炎（Chronic Hepatitis C, CHC）的临床疗效以及对肝功能和肝纤维化指标的
影响。方法：收集我院2011 年3 月至2012 年3 月收治的88 例CHC患者，随机平均分为两组，对照组单用干扰素，观察组采用干
扰素联合利巴韦林治疗，比较两组治疗后的临床疗效以及治疗前后肝功能和肝纤维化指标变化情况。结果：观察组治疗总有效率
为90.91%，明显高于对照组的68.18%，两组比较差异具有统计学意义（P<0.05）；观察组治疗后ALT 和AST 分别为（70.24± 7.94）
和（79.45± 9.72），HA、PCⅢ、CⅣ和LN分别为（76.87± 10.32）、（79.45± 9.72）、（79.76± 8.00）和（118.41± 16.97），均明显高于治疗
前和对照组，差异具有统计学意义（P<0.05）。结论：干扰素联合利巴韦林治疗慢性丙型肝炎疗效显著，可明显改善患者肝功能，具
有较好的抗纤维化作用，值得临床推广和应用。 |
| 英文摘要: |
| Objective:To explore the clinical efficacy of interferon combined with ribavirin in treating chronic hepatitis C (CHC)
and its impact on liver function and liver fibrosis indexes.Methods:88 CHC patients in our hospital from March 2011 to March 2012
were randomly divided into two groups, and the control group (n=44) was treated with interferon while the observation group (n=44) was
given interferon and ribavirin. The clinical effect and liver function and fibrosis changes were observed and compared between the two
groups.Results:The overall effective rate of the observation group was 90.91%, which was significantly higher than the control group of
68.18% (P<0.05). After the treatment, the ALT, AST, HA, PC Ⅲ, C Ⅳ and LN was (70.24± 7.94), (79.45± 9.72), (76.87± 10.32),
(79.45± 9.72), (79.76± 8.00) and (118.41± 16.97) respectively in the observation group, which were significantly higher than before
and these of the control group, the differences were statistically significant (P<0.05).Conclusion:Interferon and ribavirin show good effect
in treatingCHC. Theycansignificantlyimprove liver functionandhas anti-fibrosis function,which isworthclinical promotionand application. |
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