| 陈倩 郭燕菊 王茹 孙亚娟 王会中.临床分离肠球菌的分布特征及耐药性分析[J].现代生物医学进展英文版,2014,14(28):5544-5547. |
| 临床分离肠球菌的分布特征及耐药性分析 |
| Distribution Characteristics and Resistance Analysisof Clinical Isolates of Enterococcus |
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| DOI： |
| 中文关键词: 肠球菌 耐药性 分布特征 |
| 英文关键词: Enterococcus Resistance Distribution characteristics |
| 基金项目: |
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| 中文摘要: |
| 目的：了解我院临床分离肠球菌的分布特征及耐药现状，为临床合理用药提供依据。方法：对我院2010 年1 月至2012 年12
月期间所有临床分离的肠球菌分布情况及药敏结果进行回顾性分析。结果：临床共分离肠球菌242株，粪肠球菌分离率（55.0 %）
高于屎肠球菌（40.9 %），屎肠球菌分离率有增高的趋势。标本来源以尿液（62.9 %）、分泌物（10.3 %）、血液（6.9 %）为主。肠球菌对
万古霉素、替考拉宁的敏感性最高，均高于90%。发现耐万古霉素的肠球菌（VRE）7 株，其中5株同时耐高浓度的氨基糖苷类抗生
素（HLAR）；对克林霉素、复方磺胺、阿米卡星、庆大霉素、妥布霉素、苯唑西林耐、头孢西丁耐药率最高，均高于95 %。屎肠球菌对
青霉素类、氨苄西林、红霉素、呋喃妥因、环丙沙星耐药率均高于粪肠球菌；对四环素、奎努普丁/ 达福普汀耐药率低于粪肠球菌。
结论：肠球菌是临床感染重要病原菌，且具有多重耐药性，屎肠球菌和粪肠球菌耐药水平差异较大，临床应根据药敏结果合理选
择抗菌药物。 |
| 英文摘要: |
| Objective:To investigate the distribution characteristics and drug resistance of our hospital clinical isolates of
enterococcus, and provide the basis for the clinical use of drugs.Methods: Enterococcus distribution and susceptibility results of all
clinical isolates in our hospital from January 2010 to December 2012 were retrospectively analyzed.Results:242 strains of Enterococcus were isolated from clinical, and Enterococcus faecalis separation rate (55.0 %) was higher than Enterococcus faecium(40.9 %), while Enterococcus faecium
separation rate tended to increase. The Enterococcus was main isolated from source of specimen urine (62.9 %),secretions (10.3 %), blood (6.9 %). Enterococcus was sensitivity to Vancomycin, Teicoplanin highest, which was higher than 90 %.
Seven strains of Vancomycin- resistant Enterococcus (VRE) were detected, which were five of them at the same time resistant to high
concentrations of Aminoglycoside antibiotics (HLAR). The resistance rates of Enterococcus to Clindamycin, Sulfamethoxazole,
Amikacin, Gentamicin, Tobramycin, Oxacillin, Cefoxitin were the highest, all of them were higher than 95 %. The resistance rates of Enterococcus faecium
to Penicillin, Ampicillin, Erythromycin, Nitrofurantoin, Ciprofloxacin were higher than Enterococcus faecalis, but
the resistance rates to Tetracycline, Quinuperistin/Dalfopritin were Lower than Enterococcus faecalis .Conclusion:Enterococcus is
important pathogen of clinical infection, and has multiple drug resistance,Enterococcus faccium and Enterococcus faecalis resistance
level is quite different, and clinical rational selection of antibiotics should be based on susceptibility results. |
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