| 章洪英 朱立群 戴颖楠 李元十 韩颖 陈叶萍 富路.血管活性物质与高血压的相关性研究[J].现代生物医学进展英文版,2014,14(28):5536-5538. |
| 血管活性物质与高血压的相关性研究 |
| Relationship of Vasoactive Substences and Hypertension |
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| DOI： |
| 中文关键词: 高血压 尾加压素Ⅱ 内皮素 肾上腺髓质素 |
| 英文关键词: Hypertension Urotensin-Ⅱ Endocilin Adrenomedullin |
| 基金项目:黑龙江省教育厅基金面上项目（11521151） |
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| 中文摘要: |
| 目的：研究尾加压素Ⅱ(Urotensin -Ⅱ,U-Ⅱ)、内皮素（Endocilin ，ET）、肾上腺素质素（Adrenomedullin，ADM）在高血压患者血
浆中含量的变化并探讨其临床意义。方法：采用放射免疫法测定40 例正常人和120 例原发性高血压（所有患者既往未服用过降
压药物）患者血浆中尾加压素、内皮素、肾上腺素质素的血浆含量。结果：高血压患者血浆中U-Ⅱ、ET 及ADM含量明显高于正常
对照组（3.275± 1.257 pmol/L vs 1.802± 0.639 pmol/L, P<0.01），(65.884± 10.882 vs 51.831± 6.488 pmol/L)，(38.467± 10.496 vs
21.319± 5.646 pmol/L)。患者血浆中U-Ⅱ水平与收缩压（r=0.371, P<0.01）及舒张压（r=0.262, P<0.01）水平呈正相关。血浆中U-Ⅱ
水平与ET 水平无显著相关性（rET=0.08,P>0.05）,血浆中U-Ⅱ水平与ADM水平正相关(rADM=0.253, P<0.05)。结论：多种血管活
性物质共同参与高血压的病理生理过程。U-Ⅱ、ET 及ADM的含量变化可能作为高血压严重程度的指标。 |
| 英文摘要: |
| Objective:To observe the changes of plasma urotensin-Ⅱ, ET and ADMlevels in patients with hypertension and to illustrate
clinical significance of its changes.Methods:120 patients with HP and 40 age and gender- matched control subjects were studied.
Plasma U-Ⅱ, ET and ADM levels of 120 patients with HP and 40 control subjects were measured by radioimmunoassay.Results:The
plasma U-Ⅱ, ET and ADM levels were significantly higher in patients with HP than that in control subjects (3.275± 1.257)VS(1.802±
0.639)pmol/L, (65.884± 10.882 vs 51.831± 6.488 pmol/L), (38.467± 10.496 vs 21.319± 5.646 pmol/L). The plasma U-Ⅱ levels have
direct correlation to systolic pressure (r=0.371, P<0.01) and diastolic pressure (r=0.262, P<0.01). The plasma U-Ⅱlevels have no correlation
to ET levels (rET=0.08, P>0.05), but have direct correlation to ADMlevels(rADM=0.253, P<0.05).Conclusion:In the process of hypertension,
plasma levels of U-Ⅱ , ET and ADMshowed gradually increasing changes. U-Ⅱ, ET and ADMmight play a certain role in
the pathophysiology of HP. The plasma levels of U-Ⅱ, ET and ADMmaybe assess the severity of HP. |
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