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目的：对广东湛江地区前列腺炎患者前列腺液病原菌分布及药敏情况进行分析，为临床合理用药和制定最佳治疗方案提供依据。方法：湛江市两间最大三甲医院2009 年1 月至2013 年4 月间共308 例前列腺炎患者的前列腺液进行细菌学和药敏试验。运用全自动微生物分析仪鉴定细菌，采用K-B 法测定药物敏感性。结果：308 例前列腺液标本中，共17 例（17/308，5.52%）分离出致病菌。这些致病菌以革兰氏阳性菌为主，共13 株（13/17，76.47%），其中溶血葡萄球菌检测出6 株（6/13，46.15%），全部是耐甲氧西林凝固酶阴性葡萄球菌。革兰氏阴性菌4 例（4/17，23.53%），包括大肠埃希菌2 株（其中一株产超广谱茁-内酰胺酶(ESBLs)），粘膜炎莫拉氏菌1 株，肺炎克雷伯菌亚种1 株。结论：绝大多数前列腺炎患者属于慢性前列腺炎/ 慢性骨盆疼痛综合症，无需常规使用抗生素治疗。慢性细菌性前列腺炎致病菌感染以革兰氏阳性菌为主。对前列腺炎患者进行病原学检测及药敏试验是临床合理用药、制定最佳治疗方案的基础。

英文摘要:

Objective:Pathogen distribution and drug-sensitivity from prostatic fluid of patients with prostatitis in Zhanjiang district were analyzed to provide the basis for clinical treatment.Methods:308 patients with prostatitis were examined, who had been treated in the two largest hospitals of Zhanjiang from January 2009 to April 2013. Bacterial aerobic culture and drug-sensitivity test were performed by automatic bacterial analysis system and Kirby Bauer test, respectively.Results:17 pathogens were isolated from 308 cases (17/308, 5.52%). The main pathogens were Gram-positive bacteria, a total of 13 (13/17,76.47%), from which Hemolysis Staphylococcus were detected six (6/13,46.15%)and all cases were Methicillin-Resistant Coagulase-Negative Staphylococci (MRCNS); A total of 4 Gram-negative bacteria, accounting for 23.53% (4/17), were consisted of 2 Escherichia Coli (in which there was 1 strain of Extended-spectrum beta-lactamase), 1 Mucositis Moraxella, 1 Klebsiella pneumonia subspecies.Conclusion:The majority of patients with prostatitis is chronic prostatitis / chronic pelvic pain syndrome, which does not need the routine use of antibiotics treatment. Gram-positive bacteria are the main pathogens that cause chronic bacterial prostatitis infection. Pathogen detection and drug- sensitivity test for the patients with prostatitis provides the clinical rational drug use and the best treatment options.

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