| 康岚 赵波 颜炳柱 杨宝山 陈立艳 毕蔓茹.胱抑素在肾综合征出血热患者中的动态变化及意义[J].现代生物医学进展英文版,2014,14(28):5511-5513. |
| 胱抑素在肾综合征出血热患者中的动态变化及意义 |
| Clinical Significance and Dynamic Changes of CysC in Patients SufferingfromHemorrhagic Fever with Renal Syndrome (HFRS) |
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| DOI： |
| 中文关键词: 血清胱抑素C 肾综合征出血热 肾脏损伤 |
| 英文关键词: Serumcystatin C Hemorrhagic fever with renal syndrome Kidney injury |
| 基金项目: |
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| 中文摘要: |
| 目的：观察肾综合征出血热（HFRS）患者血清胱抑素的动态变化，并探讨其临床意义。方法：选取2010 年10 月至2013 年06
月哈尔滨医科大学附属第二医院感染科住院肾综合征出血热患者106 例为研究对象，按病期（发热期、极期、多尿期、恢复期）采
集血液标本，采用免疫比浊法检测血清胱抑素（CysC）水平，用全自动生化仪分析血尿素氮（BUN）、血肌酐(SCr)水平，比较不同分
期及分型HFRS患者的CysC 的水平，并分析CysC 与BUN 和SCr的相关性。结果：HFRS患者血清CysC 各期均明显高于健康对
照组（P＜0.05），病程极期时达高峰，多尿期时开始下降，恢复期时明显降低、但仍高于对照组；重症组患者在发病早期和极期时均
显著高于轻症组（P＜0.05）。CysC 与BUN和SCr 的Pearson 相关系数分别为r=0.7688 和r=0.8071（P＜0.05），CysC 与BUN 和
SCr 之间有很好的正相关性。结论：血清CysC 可较为敏感地反映HFRS 患者肾脏损伤，其检测对于病情的发展和预后判断均有重
要的临床意义。 |
| 英文摘要: |
| Objective:To study the dynamic changes of CysC and investigate the clinical significance in patients with HFRS.Methods:A total of 106 patients with HFRS admitted to department of infectious diseases were enrolled in this study from October 2010
to June 2013. Blood samples were collected at different phases of HFRS, and the levels of serum CysC, BUN and SCr were tested with
different methods. The levels of CysC were compared in patients among different stages and phases of HFRS, and the correlation was
analyzed.Results:The levels of serum CysC in patients with HFRS increased significantly in febrile phase, reached its peak in
hypotensive and oliguric phase and then decreased gradually in diuretic phase but still higher than that of normal in convalescent phase
（P＜0.05）. The levels of CysC, BUN and SCr in severe group were higher than in light group in different stages（P＜0.05）. The Pearson
correlation coefficient of CysC, BUN and SCr was 0.7688 and 0.8071, respectively（P＜0.05）. There existed that serumCysC had a good
positive correlation with BUN and SCr.Conclusion:Serum levels of CysC might be a sensitive indictor for kidney injury and be of
prognostic importance in patients with HFRS. |
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