| 由军 许小红 范慧子 毛春梅 车艺兰 张志程 刘丽晓.匹多莫德对反复呼吸道感染患儿外周血T 淋巴细胞亚群变化的影响及其临床疗效[J].现代生物医学进展英文版,2014,14(28):5499-5502. |
| 匹多莫德对反复呼吸道感染患儿外周血T 淋巴细胞亚群变化的影响及其临床疗效 |
| Influence of Pidotimod on the Changes of Peripheral BloodT Lymphocyte Subsets for Children with Recurrent RespiratoryTract Infection and its Curative Effects |
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| DOI： |
| 中文关键词: 反复呼吸道感染 T淋巴细胞 CD4+ CD8+ 匹多莫德 |
| 英文关键词: Recurrent respiratory tract infection T lymphocyte CD4+ CD8+ Pidotimod |
| 基金项目: |
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| 中文摘要: |
| 目的：研究匹多莫德治疗反复呼吸道感染患儿的临床疗效，并探讨其对患儿外周血T 淋巴细胞亚群变化的影响。方法：选择
我院收治的160 例反复呼吸道感染患儿，根据临床治疗方法将其分成研究组（80 例）与对照组（80 例），对照组采用抗生素或抗病
毒、退热、止咳、平喘与化痰等对症治疗，研究组则在对照组的基础上再加用匹多莫德口服。比较两组患儿外周血T 淋巴细胞亚群
变化并分析其临床疗效。结果：研究组治疗总有效率显著优于对照组（P＜0.05）。研究组治疗后CD3+、CD4+、CD4+/ CD8+水平，与治
疗前比较明显升高(P＜0.05)，与对照组同期比较具有明显的差异(P＜0.05)。研究组患儿治疗后白细胞计数及中性粒细胞水平，与
治疗前比较无明显差异(P＞0.05)，与对照组同期比较无明显差异(P＞0.05)；对照组治疗前后白细胞计数及中性粒细胞水平无明显
差异（P＞0.05）。研究组患儿咳嗽、发热、喘息、肺部啰音消失时间以及抗生素使用时间均明显少于对照组(P＜0.01)。研究组与对照
组患儿治疗过程中均未发生明显的药物不良反应。结论：匹多莫德治疗反复呼吸道感染患儿疗效确切，能有效改善T 淋巴细胞的
免疫功能，值得临床推广与应用。 |
| 英文摘要: |
| Objective:To study the clinical effect of Pi do Maude on the treatment of the recurrent respiratory tract infection for
children and to explore its influence on the changes of peripheral blood in T lymphocyte subsets.Methods:160 cases with repeated
respiratory tract who were treated in our hospital were selected and divided into the study group and control group with 80 cases in each
one. The patients in the control group were treated by antibiotics, antipyretic, relieving cough and phlegm, the asthma and other
symptomatic treatment, while the patients in the study group were treated by the pidotimod besides of the conventional methods. Then
the changes of T lymphocyte subsets and clinical efficacy of two groups with peripheral blood were observed and compared.Results:After the treatment, the total efficiency in the study group was significantly better than that of the control group (P<0.05). The levels of
CD3+, CD4+, CD4+/ CD8+ levels were higher than those of the control group with statistically significant differences (P<0.05). There was
no statistically significant difference about the white blood cell count and neutrophil levels of patients in the study group after the
treatment (P<0.05). There was no statistically significant difference between two groups (P>0.05). The symptoms of children, which
included the cough, fever, wheezing, pulmonary and antibiotic drug use in the study group were significantly less than those of the
children in the control group (P<0.01). There was no incidence of adverse reaction in the two groups.Conclusion:It is suggested that the
Pidomaude could be well promoted in the treatment of recurrent respiratory infection for children which would effectively improve the
immune function of T lymphocytes. |
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