| 曹卫娟 李青 周国艳 李桂彩 彭耀金.双时相门冬胰岛素30 联合艾塞那肽对血糖控制不佳2 型糖尿病的疗效及安全性分析[J].现代生物医学进展英文版,2014,14(28):5495-5498. |
| 双时相门冬胰岛素30 联合艾塞那肽对血糖控制不佳2 型糖尿病的疗效及安全性分析 |
| Analysis of the Efficacy and Safety of the Biphasic Insulin Aspart 30Combined with Exenatide Treating Patients with Type 2 DiabetesInadequately Controlled on Human Insulin |
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| DOI： |
| 中文关键词: 时相门冬胰岛素30 艾塞那肽 2 型糖尿病 |
| 英文关键词: Biphasic insulin aspart 30 Exenatide T2DM |
| 基金项目:湖南省教育厅资助项目（13C536） |
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| 中文摘要: |
| 目的：探讨双时相门冬胰岛素30 联合艾塞那肽在口服降糖药物和基础胰岛素血糖控制不佳的2 型糖尿病的疗效及安全
性。方法：将在我院接受治疗的72 例既往使用的口服降糖药联合基础胰岛素治疗血糖控制不佳的2 型糖尿病患者随机、平行、开
放平分成治疗组(BIAsp30+艾塞那肽治疗，早餐和晚餐前注射BIAsp30 和艾塞那肽注射液)和对照组(睡前1 次皮下注射甘精胰岛
素)，两组均与二甲双胍联合用药。比较两组治疗前后8 点血糖谱；比较两组日胰岛素用量、BMI、HbA1c 以及低血糖发生次数；比
较两组不良事件。结果：治疗8 周、16 周后，两组8个点血糖与治疗前相比均有明显下降，差异有显著性(P<0.05)；治疗8 周后、16
周后，治疗组早餐前和早餐后2 小时血糖、午餐前和午餐后2 小时血糖值分别与对照组的血糖相比，有统计学差异(P<0.05)；两组
之间的晚餐前和晚餐后2 小时血糖、睡觉前血糖( 晚上10 点)和凌晨3 点血糖相互比较无显著性差异(P>0.05)；治疗16 周后，每天
胰岛素类似物用量、BMI 组间比较无统计学意义(P>0.05)；两组治疗后HbA1c 分别与治疗前相比有统计学意义(P<0.05)，治疗组
治疗后HbA1c 与对照组治疗后HbA1c 相比，差异有显著性(P<0.05)；两组低血糖发生次数有明显差异(P<0.05)；两组不良事件次
数相互比较无统计学意义(P>0.05)。结论：BIAsp30 联合艾塞那肽可显著改善基础胰岛素联合OAD 血糖控制不佳的2 型糖尿病
患者的血糖控制，有效控制血糖，并具有良好的安全性。 |
| 英文摘要: |
| Objective:To explore the efficacy and safety the biphasic insulin aspart 30 (BIAsp30) combined with exenatide
Glargine patients with type 2 diabetes patients switching from basal integrated with oral anti-diabetic drugs.Methods:76 patients with
T2DMinadequately controlled on basal insulin with oral anti-diabetic drugs were divided randomly, openly, parallel into two groups, the
treating group (n=36) was treated BIAsp30 combined with exenatidel; while the control group was treated with (n=36) glargine. Both of
the two groups were accepted with Metformin. Comparing the glucose spectrum of 8 time points, the dosage of insulin analogs, BMI,
HbA1c, overall hypoglycemia and the adverse events between two groups.Results:After 8 weeks and 16 weeks' treatment, the blood
glucose of 8 time points at the two groups decreased, which was statistical to compare that before treatment at the same group(P<0.05);
Besides, the glucose before breakfast, glucose after breakfast, glucose before lunch, glucose after lunch in the treating groups was statistical
less than that in the control group (P<0.05); However, there was no statistical meaning to compare the remaining glucose of 4 time
points at the two groups (P>0.05); After 16 weeks' treatment, there was no statistical difference of the dosage of insulin analogs, BMI between
two group (P>0.05); and it was statistical to compare the HbA1c in the treating group than that in the control group (P<0.05); the
HbA1c after treatment in the treating group was less that that after treatment in the control group (P<0.05); there was no statistical difference
of the overall hypoglycemia and the adverse events between two groups(P>0.05). |
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