| 丁彦 袁小亮 范海伟 曾治平 刘惟优.TGF-beta1 在不同类型特发性间质性肺炎患者肺组织中的表达及其意义[J].现代生物医学进展英文版,2014,14(28):5491-5494. |
| TGF-beta1 在不同类型特发性间质性肺炎患者肺组织中的表达及其意义 |
| Expression and Significance of TGF-beta 1 in Lung Tissuesof Patients with Different Types of IdiopathicInterstitial Pneumonia |
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| DOI： |
| 中文关键词: 转化生长因子 特发性间质性肺炎 肺组织 表达 |
| 英文关键词: Transforming growth factor Idiopathic interstitial pneumonia Lung tissue Expression |
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| 中文摘要: |
| 目的：探讨TGF-茁1 在不同类型特发性间质性肺炎患者肺组织中的表达及其意义。方法：选取2010 年2 月至2013 年12 月
在我院就诊的72 例经支气管镜肺活检的不同类型的特发性间质性肺炎患者的组织标本，对其转化生长因子-beta1表达程度进行评定。结果：寻常型（普通型）、非特异性、脱屑性、急性等IIP、呼吸性细支气管炎并间质性肺疾病以及隐原性机化性肺炎患者肺组织中TGF-beta1表达强度评分均显著高于对照组；脱屑性IIP 和呼吸性细支气管炎并间质性肺疾病患者肺组织中TGF-beta1 表达强度评分均显著高于其他类型IIP 患者；非特异性IIP、急性IIP、淋巴细胞性IIP 以及隐原性机化性肺炎组患者肺组织中TGF-beta1 表达强度评分均显著低于寻常型（普通型）IIP 组；隐原性机化性肺炎、淋巴细胞性IIP 组患者肺组织中TGF-beta1 表达强度评分分别为（0.93± 0.34）分、（0.82± 0.27）分，显著低于急性IIP组患者的（1.64± 0.05）分。差异均有统计学意义（P<0.05）。结论：TGF-beta1表达过度可能是IIP患者的重要特征，在肺纤维化的过程中发挥着重要作用，但在不同类型IIP 中的作用机制并不相同。 |
| 英文摘要: |
| Objective:To investigate the expression and significance of TGF-beta1 in lung tissue of patients with different types of
idiopathic interstitial pneumonia.Methods:72 cases of bronchoscopic lung biopsy tissue samples from patients with different types of
idiopathic interstitial pneumonia in our hospital from February 2010 to December 2013 were selected, the expression level of the
transforming growth factor-beta1 was assessed.Results:The expression intensity scores of TGF-beta1 in lung tissue in patients with Vulgaris
(common type) interstitial pneumonia, nonspecific interstitial pneumonia, desquamative interstitial pneumonia, acute, such as interstitial
pneumonia, respiratory bronchiolitis associated with interstitial lung disease, and cryptogenic organizing pneumonia, were significantly
higher; In types of desquamative interstitial pneumonia , respiratory bronchiolitis associated with interstitial lung disease , the intensity
ratings of TGF-beta1 expression in the lung tissues were significantly higher than in patients with other types of IIP; In nonspecific
interstitial pneumonia, acute interstitial pneumonia, cryptogenic organizing pneumonia and lymphocytic interstitial pneumonia, TGF-beta1
expression were significantly lower than in ordinary interstitial pneumonia group; The intensity scores of lung tissue TGF-beta1 expression
for group cryptogenic organizing pneumonia and lymphocytic interstitial pneumonia were (0.93± 0.34) points and (0.82± 0.27) points
respectively, and were both significantly lower than that of the group of acute interstitial pneumonia(1.64± 0.05 points). Differences were
statistically significant (P<0.05).Conclusion:TGF-beta1 expression may be an important feature of excessive IIP patients, and plays an
important role in the process of pulmonary fibrosis, but the action mechanisms of TGF-beta1 in different types of IIP are not the same. |
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