| 张永国 邵晓冬 王红红 李宏宇 郭晓钟.EMT 标志分子Vimentin在胃癌中的表达和临床意义[J].现代生物医学进展英文版,2014,14(28):5479-5482. |
| EMT 标志分子Vimentin在胃癌中的表达和临床意义 |
| Expression of Vimentin and Its Clinical Significance in HumanGastric Cancer |
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| DOI： |
| 中文关键词: Vimentin 胃癌 转移 |
| 英文关键词: Vimentin Gastric cancer Metastasis |
| 基金项目:国家自然科学基金项目（81101891） |
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| 中文摘要: |
| 目的：探讨EMT标志分子Vimentin 在胃癌中的表达和临床意义。方法：利用免疫组化染色的方法检测Vimentin 在120 例
胃癌及其相应癌旁组织中的表达，统计分析Vimentin 的表达水平与年龄、性别、组织学类型、TNM 分期、淋巴结转移等临床病理
特征间的相关性。结果：Vimentin 在胃癌中的表达阳性率为55.8%，远高于相应癌旁组织的22.5%(P<0.01)，进一步分析研究发现
Vimentin 的表达水平在Ⅲ 和Ⅳ期的胃癌中（TNM 分期）的表达明显高于Ⅰ和Ⅱ期的胃癌，差异具有统计学意义(P=0.009)，在发生
淋巴结转移胃癌中表达明显高于未发生淋巴结转移的胃癌，差异具有统计学意义(P<0.000)。结论：Vimentin 在胃癌中高表达，其
表达水平与TNM分期、淋巴结转移密切相关，提示Vimentin 在胃癌的转移过程中可能发挥重要作用。 |
| 英文摘要: |
| Objective:To investigate the expression of Vimentin in gastric cancer and analyze the relationship between Vimentin
expression and clinicopathologic features.Methods:IHC was performed to detect the expression of Vimentin in 120 cases of gastric
cancer and the corresponding adjacent non-tumor tissues. The correlation between Vimentin expression and clinicopathologic features
were analyzed.Results:Vimentin was detected in 22.5% of the adjacent non-tumor tissues. However, a high positive staining was
identified in 55.8 % of the gastric cancer tissues. Further analysis showed there was higher expression level of Vimentin in Ⅲ and Ⅳ
stages gastric cancer or with lymph node metastasis than that inⅠ andⅡ stages or without lymph node metastasis, but there was no
difference between Vimentin expression and sex, age, or histologic grade.Conclusion:Vimentin over-expressed in gastric cancer. The
expression level of Vimentin is correlated with TNMstage and lymph node metastasis. These findings indicate that Vimentin may play an
important role in the gastric cancer metastasis. |
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