| 马艳艳 刘颖 张璟卓 王健琳 范秋阳 邱天爽.兔肝VX2 肿瘤射频消融术后残癌中基质金属蛋白酶9 表达[J].现代生物医学进展英文版,2014,14(28):5440-5442. |
| 兔肝VX2 肿瘤射频消融术后残癌中基质金属蛋白酶9 表达 |
| The Expression of the MMP-9 in Rabbit Liver VX2 Tumor-remnantTissues after Radio-frequency Ablation |
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| DOI： |
| 中文关键词: VX2 肿瘤 射频消融 基质金属蛋白酶9 超声检查 |
| 英文关键词: VX2 carcinoma Radio-frequency ablation MMP-9 Ultrasonography |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨兔肝脏VX2 肿瘤射频消融术（radio-frequency ablation，RFA）后残余肿瘤组织中基质金属蛋白酶9（MMP-9）表
达。方法：超声引导下将VX2 肿瘤组织块接种于23 只新西兰大白兔肝脏中，造模成功后随机分为5 组，对照组（A 组, n=3），不行
RFA 治疗；余20 只为实验组行RFA 治疗，在超声引导下射频针插入肿瘤偏心位置，展开电极致损毁范围最大为肿瘤总体积的
2/3，人为造成残存肿瘤组织。根据治疗结束后不同时间点分为4 组：0 小时组（B 组, n=5）、术后1 周组（C 组, n=5）、术后2 周组（D
组, n=5）、术后4 周组（E 组, n=5），行超声检查结束后处死大白兔，取肿瘤组织采取免疫组化法观察残存肿瘤组织中及未治疗肿
瘤组中MMP-9 的表达情况。结果：RFA 术后0 小时、1 周、2 周、4 周残存肿瘤组织中MMP-9 的表达均较对照组明显降低（P＜
0.05）。结论：RFA 治疗后残存肿瘤细胞中MMP-9 水平表达减低。 |
| 英文摘要: |
| Objective:To investigate the expression of the MMP-9 in rabbit liver VX2 tumor-remnant tissues after radio-frequency
ablation treatment (RFA).Methods:Ultrasound-guided the VX2 tumor mass were planted into the liver of 23 New Zealand rabbits,
models of rabbit VX2 liver tumor were divided into 5 groups at random, there were 3 rabbits in group A as the control group with no
RFA treatment; the remaining 20 rabbits as experimental group with the RFA treatment, Ultrasound-guided the Rf needle was inserted
into the location of the liver tumor eccentric, tumor-remnant tissues were remained by opening the electrode to control the maximum
damage range of total tumor volume 2/3. 20 rabbits were divided into 4 groups according to their different time after treatment, that was
after RFA group (B group), one week after RFA group (C group), two weeks after RFA group (D group), four weeks after RFA group(E
group), 5 rats in each group. The rabbits were executed after taking ultrasonographical examination, Immunohistochemistry was used to
detect the expression status of MMP-9 in rabbit liver VX2 tumor-remnant tissues after RFA treatment and the untreated tumor tissues.Results:The expression of MMP-9 in tumor-remnant tissues of 0 hour, 1 week, 2 weeks, 4 weeks after RFA were significantly lower than
the control group (P<0.05).Conclusion:After RFA the expression of MMP-9 in the remnant tumor cells is decreased. |
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