李惠晨 叶明翔 侯赟 赖晓凤 马勇政 韦伊芳 张健.TET 蛋白去甲基化作用的相关研究进展[J].现代生物医学进展英文版,2014,14(27):5361-5364. |
TET 蛋白去甲基化作用的相关研究进展 |
The Research Progress of TET Proteins on DNA De-methylation |
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DOI: |
中文关键词: TET 蛋白 DNA去甲基化 肿瘤 |
英文关键词: TET proteins DNA de-methylation Tumor |
基金项目:国家自然科学基金项目(81372390) |
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中文摘要: |
摘要:TET( ten-eleven translocation)蛋白属于酮戊二酸和Fe2+依赖的双加氧酶,能够产生催化氧化作用。在TET 蛋白家族的催化
氧化作用下5- 甲基胞嘧啶(5-methylcytosine, 5mC)可转化为5- 羟甲基胞嘧啶(5-hydroxymethylcytosine, 5hmC),并可进一步转化
为5- 甲酰胞嘧啶(5-formylcytosine, 5fC)和5- 羧基胞嘧啶(5-carboxylcytosine, 5caC)。TET 蛋白在DNA 胞嘧啶的去甲基化、胚胎
发育和基因重新编码等过程都存在重要作用,其中TET 蛋白参与DNA胞嘧啶的去甲基化过程的作用机制一直是研究热点,另
外,有研究发现TET 与肿瘤的发生也存在联系,可能成为新的肿瘤分子标志。 |
英文摘要: |
TET (ten-eleven translocation) proteins belong to alpha-ketoglutaric acid (KG) and Fe2+-dependent dioxygenasesin
which can catalyze an oxidative process. The 5-methylcytosine (5mC) can be converted to 5-hydroxy-methylcytosine (5hmC) by TET
proteins family, and can successively be oxidized to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) in DNA. The TET proteins
have an important role in DNA de-methylation, embryonic development and reprogramming. The role of TET proteins in DNA
de-methylation has been a hot research. Further, studies have found that TET proteins also have an important role in cancer and TET
proteins may become a new molecular marker of tumor. |
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