| 李志刚 梁路昌 邹岳萍 郝建明 刘剑.三金排石汤对特发性钙结石患者24 小时尿成石危险因素水平的影响[J].现代生物医学进展英文版,2014,14(27):5315-5319. |
| 三金排石汤对特发性钙结石患者24 小时尿成石危险因素水平的影响 |
| The Effect of Sanjin Paishi Tang s’Intervention on the Levels of 24-hourUrinary Stone Risk Factors in Patients with Idiopathic CalciumStone |
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| DOI： |
| 中文关键词: 特发性钙结石 三金排石汤 24 小时尿成石危险因素 |
| 英文关键词: Idiopathic calciumurolithiasis Sanjin Paishi Tang 24-hour urinary stone risk factors |
| 基金项目:湖南省科技厅科研项目（2013SK3262）；湖南省中医药管理局科研项目（201385） |
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| 中文摘要: |
| 目的：分析三金排石汤对特发性钙结石患者24 小时尿成石危险因素水平的影响，探讨其用于预防手术取石后的特发性钙
结石患者结石复发的临床价值。方法：选择2009 年9 月～2013年9 月入住我院的经皮肾镜取石术或输尿管镜取石术治疗的特发
性钙结石患者100 例，前瞻性将其随机分为治疗组和观察组，两组各50 例。治疗组予三金排石汤每日一剂分两次煎服，观察组予
正常饮食，测定和比较两组患者治疗前和治疗1 个月后的24 小时尿成石危险因素水平。结果：治疗1 个月后，观察组24 小时尿
成石危险因素水平与治疗前比较差异均无统计学意义(P>0.05)；治疗组24 小时尿量较治疗前显著增加，尿pH值、尿枸橼酸含量
明显升高，尿钙显著降低，差异均有统计学意义(P<0.05)，但尿钠、尿镁、尿磷、尿尿酸及尿草酸水平与治疗前比较差异均无统计学
意义(P>0.05)；与观察组比较，治疗组24 小时尿量明显增加，尿pH值、尿枸橼酸含量显著升高，尿钙水平明显降低，差异均有统计
学意义(P<0.05)，但两组尿钠、尿镁、尿磷、尿尿酸及尿草酸水平比较差异均无统计学意义(P>0.05)。结论：三金排石汤治疗手术取
石后特发性钙结石患者能够显著增加其24 小时尿量及尿枸橼酸含量，并减少尿钙含量，抑制结石形成，这可能有助于降低特发
性钙结石患者手术取石后的复发风险，值得临床研究和推广。 |
| 英文摘要: |
| Objective:To Analyze the effect of Sanjin Paishi Tang on the levels of 24-hour Urinary Stone Risk Factors in patients
with idiopathic calcium stone, and explore the clinical value of it on the prevention of recurrence of patients with idiopathic calcium
stone underwent calculus removed surgery.Methods:100 cases of patients with idiopathic calcium stone were selected in our hospital
fromSeptember 2009 to September 2013, and were randomly divided into the treatment group (n=50) and observation group (n=50). The
treatment group was treated by Sanjin paishi Tang twice a day, while the observation group had normal diet. The levels of 24-hour
urinary stone risk factors before and one month after the treatment were measured and compared between the two groups.Results:After
1 month’treatment, the levels of 24-hour urinary stone risk factors of observation group had no statistical difference compared with those
before treatment(P>0.05). The urine output, pH of urine and urinary citrate of treatment group were all increased significantly and urinary
calcium was obviously decreased (P<0.05). but no significant difference was found in the levels of ingredients in urine such as sodium,
magnesium, phosphorus, uric acid and urinary oxalate (P>0.05). Compared with the observation group, the urine output, pH of urine and
urinary citrate of the treatment group increased significantly and urinary calcium decreased (P<0.05), but no significant difference was
found in the levels of ingredients in urine such as sodium, magnesium, phosphorus, uric acid and urinary oxalate between the observation
group and the treatment group (P>0.05).Conclusion:Sanjin Paishi Tang could effectively increase the the urine output and urinary
cirtrate, decrease the excretion of urinary calcium and inhibit lithogenesis in the treatment of patients with idiopathic calcium stone
underwent calculus removed surgery, which may be useful to decrease the risk of recurrence of patients with idiopathic calcium stone
underwent calculus removed surgery. |
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