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目的：探讨异氟烷复合硬膜外麻醉对腹部手术患者围手术期应激性高血糖的影响。方法：选取在我院行腹腔手术的患者60 例，随机分为异氟醚复合连续硬膜外麻醉组(研究组)、异氟醚吸入全麻组( 对照组)两组，每组30 例，分析两组患者不同时间点的血糖、红细胞醛糖还原酶(AR)、丙二醛(MDA)、血浆谷胱甘肽(GSH)、一氧化氮(NO)水平变化。结果：两组的血糖差异有统计学意义（P<0.05），两组的AR、MDA、GSH 及NO差异无统计学意义（P>0.05）；不同时间点的血糖、MDA、NO 差异有统计学意义（P<0. 05），不同时间点的AR、GSH差异无统计学意义（P>0.05）；分组与时间之间对血糖、AR、MDA、GSH 无明显的交互作用（P>0.05），分组与时间之间对NO有交互作用（P<0.05）。结论：腹腔手术存在应激性高血糖反应，采用异氟烷复合硬膜外麻醉可降低应激性高血糖的影响。

英文摘要:

Objective:To investigate the effect of isoflurane inhalation combined with epidural anesthesia on the stress hyperclycemia of RBC in patients under-going abdominal surgery.Methods:60 patients in our hospital undergoing abdominal surgery were randomly divided into isoflurane continuous epidural anesthesia group (study group) and isoflurane anesthesia group(control group), each group of 30 cases subjects, analysis the levels of blood glucose, aldose reductase (AR), malondialdehyde(MDA), plasma glutathione (GSH), nitric oxide (NO) at different time points.Results:The blood glucose between the two groups was statistically significant (P<0. 05), AR, MDA, GSH and NO was not statistically significant difference (P>0.05); blood glucose, MDA, NO at different time points were statistical significant difference (P <0.05), AR, GSH at different time points were no significant difference (P> 0.05); between group and time on blood glucose, AR, MDA, GSH was no significant interaction(P>0.05), NO had the interaction between group and time (P<0.05).Conclusion:The presence of abdominal surgery stress hyperglycemia, epidural anesthesia using isoflurane can reduce the effects of stress hyperglycemia.

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