| 曲光瑾 关紫健 许传顺 罗善顺 王德润 韩辉.中老年男性缺血性脑血管病与阻塞性睡眠呼吸暂停综合症的临床相关性分析[J].现代生物医学进展英文版,2014,14(27):5270-5273. |
| 中老年男性缺血性脑血管病与阻塞性睡眠呼吸暂停综合症的临床相关性分析 |
| The Correlation Analysis of Middle Aged and Old Male with IschemicCerebrovascular Disease and Obstructive Sleep Apnea Syndrome |
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| DOI： |
| 中文关键词: 缺血性脑血管病 睡眠呼吸暂停综合症 睡眠呼吸暂停低通气指数 危险因素 |
| 英文关键词: Ischemic cerebrovascular disease Sleep apnea syndrome (OSA) Apnea hypopnea index(AHI) Risk factor |
| 基金项目: |
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| 中文摘要: |
| 目的：对中老年男性缺血性脑血管病合并阻塞性睡眠呼吸暂停综合症（obstructive sleep apnea，OSA）的相关性及其危险因素
进行临床分析。方法：选择中老年男性急性脑梗死患者(acute cerebral infarction，ACI）40 例，短暂性脑缺血发作患者(transient
ischemic attack, TIA)36 例及健康对照组患者36 例用多导睡眠呼吸监测仪进行监测，对患有OSA的患者根据睡眠呼吸暂停低通
气指数(apnea hypopnea index，AHI）分成轻中重三组，并对其临床指标及危险因素进行分析。结果：ACI 组(15.3± 12.3)和TIA 组
(14.7± 10.4)患者AHI显著高于对照组（8.2± 6.6，P<0.01）。OSA 在各组中的发病率分别为60.0%，52.8%和22.2%，与对照组有显
著差异。缺血性脑血管病患者的体重指数（BMI），血糖，纤维蛋白原(FIB)，胆固醇水平(CHOL)，高密度脂蛋白（HDL）以及烟酒等不
良嗜好与OSA呈正相关。中重度OSA 患者缺血性脑血管病的发病率显著高于轻症患者（P<0.01）。结论：OSA是影响老年男性缺
血性脑血管病发病的重要因素，其严重程度可能与缺血性脑血管病成正相关。 |
| 英文摘要: |
| Objective:To investigate the relationship between the ischemic cerebrovascular disease and the obstructive sleep
apnea syndrome (OSA) and to analyze the risk factors of them.Methods:40 old male patients at the age of medium with the acute
cerebral infarction(ACI), 36 patients with transient ischemic attack (TIA) and another 36 age-matched healthy people were selected and
detected by polysomnography (PSG). Then the patients with OSA were divided into three groups and the clinical indicators and risk
factors were analyzed.Results:The mean level of AHI was (14.7± 10.4) in TIA and (15.3± 12.3) in ACI which was significantly higher
than those of the controls (8.2± 6.6; P<0.01). The prevalences of OSA were 60.0% in ACI, 52.8% in TIA and 22.2% in controls. The
body mass indicts (BMI), blood sugar, fibrinogen, cholesterol, high density lipoprotein, smoke and alcohol of patients with OSA were
significantly higher than those of the patients without OSA. The incidence of ischemic cerebrovascular diseases happened to the patients
with OSA who were suffered from the moderate to the severe were higher than those of the mild ones.Conclusion:OSA is associated
with cerebrovascular disease in middle aged and old male patients. The severity of OSA maybe associated with ischemic cerebrovascular
disease. |
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