| 黄炳坤 莫莉 陈安叶 张春蓉 尹志华.糖化血清白蛋白检测对2 型糖尿病患者短期血糖控制的疗效评价[J].现代生物医学进展英文版,2014,14(26):5139-5142. |
| 糖化血清白蛋白检测对2 型糖尿病患者短期血糖控制的疗效评价 |
| Detection of Glycated Albumin on the Evaluation of Short TermGlycemicControl for Patients with Type 2 Diabetes |
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| DOI： |
| 中文关键词: 2型糖尿病 血清白蛋白 检测 |
| 英文关键词: Type 2 Diabetes Mullites Glycated albumin Measurement |
| 基金项目:深圳市医学重点学科建设资助项目（2005C10） |
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| 中文摘要: |
| 目的：探讨糖化血清白蛋白（glycate dalbumin, GA）作为反映近期（2 周内）血糖控制总体水平的指标在糖尿病人群中的临床
应用价值。方法：选取2010 年6 月-2013 年7 月间深圳市福田区中医院住院的2 型糖尿病(T2DM)患者323 例，测定空腹血糖
（FPG）、餐后2 小时血糖（2hPG）、1 日指尖血糖谱均值（MBG）、GA、糖化血红蛋白（HbAlc）等，并对其中92 例住院近2 周的患者
分别在入院后6 天及12 天复查上述指标。结果：GA 与HbAlc（r=0.791），FPG（r=0.541），2hPG（r=0.456），MBG（r=0.401），均呈正相
关（P 均<0.01）；患者入院6 天检测GA 为（27.1± 5.45）％，入院12 天为（22.77± 4.34）％，均显著低于入院第一天的（30.31±
6.75）％（P<0.01）；入院6 天和12 天，患者的GA 较入院时分别下降3.12％和7.54％（P<0.01）；HbAlC 分别下降0.31％和0.78％，
GA下降降幅显著大于HbAlc（P<0.01）。结论：GA可及时、准确的反映短期（1～2 周）平均血糖的变化情况，并与长期血糖控制的
金标准HbAlC 有良好的相关性，是监测糖尿病患者血糖控制的良好指标。 |
| 英文摘要: |
| Objective:To investigate the clinical value of glycated albumin reflective indicator of the general monitoring standard
of blood glucose in the diabetics patients.Methods:323 patients with Type 2 Diabetes Mullites (T2DM) who were treated in our hospital
between June 2010 and July 2013 were enrolled in the study. The fasting plasma-glucose (FPG), two-hours' postprandial blood glucose
(2hPG), MGB, GA and HbAlc of patients were detected and evaluated. The above parameters were measured again respectively on the
6th and the 12th day.Results:A positive relation of GA value, HbAlc, FPG, 2hPG and MBG was found with the coefficient index of
0.791, 0.541, 0.456 and 0.401, respectively (P<0.01); On the 6th day after the admission, the mean level of GA in the 92 patients was
（27.1± 5.45）%, and the 12th day was（22.77± 4.34）% that were both significantly lower than (30.31± 6.75)% in the first day(P<0.01);
After the admission for 6 and 12 days, the GA level of patients decreased in 3.12%and 7.54%, respectively(P<0.1), when compared with
that of the first day; The HbAlc level was decreased in 0.31%and 0.78%, respectively(P<0.1). The decreasing degree of GA was greater
than that of HbAlc (P<0.01).Conclusion:The level of GA can reflect the short-term changes of the mean level of blood glucose in an
immediate and exact way. Meanwhile, it was well correlated with HbAlC which was the gold standard of long-term diabetic controlling,
as well as a good indicator for monitoring blood glucose control of the diabetic patients. |
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