| 曾赛田 郭亮 刘世凯 王东晖 奚杰 高洁凡 冯静 张亮.二次肿瘤细胞减灭术在铂类敏感的复发性卵巢上皮癌中的作用[J].现代生物医学进展英文版,2014,14(26):5109-5011. |
| 二次肿瘤细胞减灭术在铂类敏感的复发性卵巢上皮癌中的作用 |
| Role of Secondary Cytoreductive Surgery for Patients with PlatinumSensitive Recurrent Epithelial Ovarian Cancer |
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| DOI： |
| 中文关键词: 肿瘤细胞减灭术 卵巢癌 复发 生存期 |
| 英文关键词: Cytoreductive surgery Ovarian cancer Recurrent Survival |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨二次肿瘤细胞减灭术对铂类敏感的复发性卵巢上皮癌治疗的临床意义。方法：回顾性分析我院于2002 年1 月至
2012 年12 月收治的115 例铂类敏感的复发性卵巢上皮癌患者的临床及随访资料。结果：在115 例铂类敏感的复发性卵巢上皮癌
中，66例接受了二次肿瘤细胞减灭术（手术组），术后辅以铂类为基础的化疗。49 例患者只接受了以铂类为基础的化疗（对照组）。
两组患者肿瘤病理分型无统计学差异（P=0.485）。与对照组相比，手术组FIGO 分期IV 期患者的比例少（15.2% VS 34.7%，
P=0.014），低分化患者的比例少（71.2%VS 91.8%，P=0.024），多发复发病灶患者的比例少（28.3%VS 49.0%，P=0.027）。平均随访
30.2 个月（6-48 个月），Kaplan-Meier生存分析显示，手术组与对照组患者的中位生存期分别为35.0 个月和27.0 个月，差异有统计
学差异（Log rank 7.9，P=0.005）。多因素Cox 回归分析显示，校正了年龄、肿瘤病理类型、病理分级及FIGO分期后，不同治疗方案
是复发上皮性卵巢癌患者远期生存率的独立影响因素。结论：二次肿瘤细胞减灭术可以改善铂类敏感的复发性卵巢上皮癌患者
的临床预后。 |
| 英文摘要: |
| Objective:To investigate the clinical benefit of secondary cytoreductive surgery for patients with platinum sensitive
recurrent epithelial ovarian cancer.Methods:The clinical and follow-up data of 115 patients with recurrent epithelial ovarian cancer
treated in our department between January 2002 and December 2012 were retrospectively analyzed.Results:66 patients underwent
secondary cytoreductive surgery assisted by platinum based chemotherapy (operation group), and other 49 patients were treated with
chemotherapy only(control group).Patient's tumor pathological types of two groups were of no statistical difference(P=0.485). Compared
with the control group, FIGO clinical stage IV Patients were fewer in operation group (15.2%VS 34.7%,P=0.014), poorly differentiated
carcinoma patients were fewer in operation group(71.2%VS 91.8%，P=0.024), multiple recurrent lesions patients were fewer in operation
group (28.3% VS 49.0%，P=0.0270). All patients were followed up for the average follow-up of 30.2 months (range 6-48 months).
Kaplan-Meier survival analysis showed that the median survival time was significantly different between the two groups (35 months VS
27 months, Log rank 7.9, P=0.005). Cox regression multivariate analysis showed that with adjustment for age, pathological type,
pathological grading and FIGO clinical staging, different treatments were the independent predictors of recurrent epithelial ovarian
carcinoma patients with long-term survival rate.Conclusion:The secondary cytoreductive surgery may improve the prognosis of patients
with recurrent, platinum-sensitive epithelial ovarian carcinoma. |
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