| 罗年安 屈亚琦 张洪科 李人立 董瑞.HuR 和PDGFC 在乳腺癌组织中的表达及相关性分析[J].现代生物医学进展英文版,2014,14(26):5011-5013. |
| HuR 和PDGFC 在乳腺癌组织中的表达及相关性分析 |
| Expressions of HuR and PDGFC in Breast Cancer and its CorrelationAnalysis |
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| DOI： |
| 中文关键词: 乳腺肿瘤 HuR PDGFC 免疫组织化学 |
| 英文关键词: Breast neoplasms HuR PDGFC Immunohistochemistry |
| 基金项目:国家自然科学青年基金项目（811001181） |
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| 中文摘要: |
| 目的：探讨HuR 和PDGFC 在乳腺癌组织中的表达及相关性。方法：选取2008 年至2009 年80 例手术切除并有完整的临床
与病理资料的乳腺癌患者为研究对象，采用免疫组化法对乳腺癌组织中HuR和PDGFC的表达进行检测，并进行统计学分析。分
析两者的表达与乳腺癌pTNM分期的关系，以及两者之间的相关性。结果：乳腺癌组织中HuR和PDGFC 的表达均与pTNM分
期有相关性(均P<0.05)，且两者的表达呈正相关(r=0.608, P>0.05 )，具有统计学意义。结论：乳腺癌中HuR 和PDGFC 的高表达可
能参与了乳腺癌的发生发展过程，有望影响乳腺癌的术后治疗。两者的表达产物呈正相关，HuR 的表达产物可能通过对PDGFC
的表达进行调控促进乳腺癌的发生与发展。 |
| 英文摘要: |
| Objective:To investigate the expressions of HuR and PDGFC in breast cancer and its correlation.Methods:From2008
to 2009, 80 cases of surgical operation and clinical and pathological data of breast cancer patients as the research object.The expressions
of HuR and PDGFC in breast cancer tissue samples were detected by immunohistochemical techniques and analyzed statistically. The
correlation between expressions of both genes and pTNM stages were analysed as well as correlation between them.Results:Both of
their expressions were correlated with pTNMstages(P<0.05), and there was positive correlation between expression of HuR and PDGFC
(r=0.608, P>0.05), which is statistically significant.Conclusion:The high expressions of HuR and PDGFC possibly participated the
procession of the tumogenesis growth and prognosis of breast cancer which may play a very important role in the therapy after operation.
Their expressions are positively correlated, the products of HuR expression may play an important role on the in set and progression of
breast cancer by regulating the expression of PDGFC. |
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