| 栾晓 高胜利 刘虹 逄明杰 祝海 王萍 公衍玲 郭菲菲 孙向荣 徐珞.Ghrelin 对心肌梗死大鼠恶性心律失常和早期左室重构的影响[J].现代生物医学进展英文版,2014,14(26):5005-5010. |
| Ghrelin 对心肌梗死大鼠恶性心律失常和早期左室重构的影响 |
| Ghrelin Prevents Malignant Arrhythmia and Early Left Ventricular Remodeling in Rats with Myocardial Infarction |
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| DOI： |
| 中文关键词: Ghrelin 心肌梗死 左心室重构 心律失常 |
| 英文关键词: Ghrelin Myocardial infarction Left ventricular remodeling Cardiac arrythmias |
| 基金项目:国家自然科学基金项目(30670780；31071014；81100260；81270460)；山东省科技攻关项目(2008GG10002006)； |
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| 中文摘要: |
| 目的：本文主要研究ghrelin 对心肌梗死大鼠恶性心律失常和早期左室重构的影响。方法：心肌梗死大鼠模型每天两次注射
ghrelin(100 滋g/kg)或生理盐水。通过超声心动图评估大鼠的心脏重量并且观察大鼠的血流动力学。使用酶免疫分析法测定血清胰
岛素生长因子I(IGF-1)、血浆肾上腺素、去甲肾上腺素和多巴胺的浓度。注射药物前后分析大鼠的神经功能。结果：与对照组相比，
ghrelin 治疗的心肌梗死模型大鼠生存率显著增加(P< 0.05)，心脏功能增强，但心肌梗死面积差异不大(P> 0.05)。结论：Ghrelin 能
够提高心肌梗死模型大鼠的生存率、缓解心肌梗死大鼠心率失常、改善心肌梗死大鼠左心室重构。 |
| 英文摘要: |
| Objective:To investigate the effects of ghrelin on the cardiovascular system in rats with myocardial infarction (MI),
such as preventing malignant arrhythmia, delaying left ventricular remodeling and decreasing mortality.Methods:Ghrelin (100 ug/kg sc,
twice daily) or saline were administered for 2 weeks from the day of MI operation in Wistar rats. The effects of ghrelin on cardiac
remodeling were evaluated by echocardiographic and hemodynamic. Serum insulin-like growth factor I (IGF-I), plasma concentrations of
epinephrine, norepinephrine, and dopamine were measured by using enzyme immunoassay kit. Before and after ghrelin (100 ug/kg sc)
was administered in conscious rats with MI, the autonomic nervous function was investigated by power spectral analysis obtained by a
telemetry system.Results:Results showed that compared with that in the control group rats, the percent survival of ghrelin treated rats
increased significantly (P< 0.05), the cardiac function enhanced remarkably, but the size of the infarct of the left ventricular wall did not
significantly differ between MI + NS rats and MI + Ghrelin rats (P> 0.05).Conclusion:Ghrelin can increase the survival rate, improve
cardiac arrythmias and alleviate left ventricular remodeling of myocardial infarction rats. |
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