| 任翔 吴剑 李嘉航 武龙 董世武.Wnt/beta-catenin 通路在成骨细胞中的作用[J].现代生物医学进展英文版,2014,14(25):4991-4993. |
| Wnt/beta-catenin 通路在成骨细胞中的作用 |
| Role of Osteoblasts in Wnt / beta-catenin Pathway |
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| DOI： |
| 中文关键词: Wnt/beta-catenin 通路 成骨细胞 分化增殖 |
| 英文关键词: Wnt / beta-catenin pathway Osteoblasts Differentiation and proliferation |
| 基金项目: |
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| 中文摘要: |
| Wnt 信号通路包括经典通路和非经典通路两种，其中Wnt 经典通路又称为Wnt/beta-catenin 通路，其在成骨细胞的分化、增殖过程中发挥这重要的作用。Wnt信号通路实现过程中有多种因子参与，包括Wnt 蛋白、beta-catenin、蛋白激酶GSK-3beta以及APC 蛋白等多种。Wnt蛋白家族是由19 种Wnt 蛋白组成的，主要分为经典Wnt蛋白和非经典Wnt蛋白，其本质是一系列高度保守的分泌性糖蛋白，并且不同的Wnt蛋白对成骨细胞发挥着不同的作用，其中经典Wnt 蛋白通过经典Wnt 信号作用于成骨细胞对成骨
细胞的增殖、分化有着重要的影响。本综述通过对Wnt经典信号通路过程中的多种因子与成骨细胞分化、增殖的关系进行分析总结，了解Wnt/beta-catenin 通路对成骨细胞的作用。 |
| 英文摘要: |
| Wnt signaling pathway was consisted of the classical pathway and non-classical pathway, wherein the Wnt pathway
is also called the classical Wnt / beta-catenin pathway, in which the proliferation may play an important role in the differentiation of
osteoblasts. Wnt signaling pathway was involved in the process of a variety of factors which includes the Wnt proteins, the beta-catenin, a protein kinase GSK-3beta and the APC protein. Wnt protein family is composed of 19 kinds of Wnt proteins, mainly divided into canonical Wnt proteins and non-canonical Wnt proteins, which is essentially a series of highly conserved secreted glycoproteins, and is different on
osteoblasts, where the proliferation of canonical Wnt canonical Wnt signaling protein by acting on osteoblasts on osteoblast
differentiation has important implications. This review aims at the classic Wnt signaling pathway by a variety of factors and the process of osteoblast differentiation and proliferation were analyzed and summarized the relationship, understanding the role of Wnt / beta-catenin pathway in osteoblasts. |
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