| 付娟娟 宋新兰 王春 虞海荣 胡小萍.新疆女性乳腺癌657 例临床病理分析[J].现代生物医学进展英文版,2014,14(25):4932-4935. |
| 新疆女性乳腺癌657 例临床病理分析 |
| Clinicopathological Analysis of 657 cases of Women with Breast Cancerin Xinjiang |
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| DOI： |
| 中文关键词: 乳腺癌 民族 病理学特征 三阴癌 BRCA1 |
| 英文关键词: Breast cancer Ethnic Pathology Clinical data of national BRCA1 |
| 基金项目: |
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| 中文摘要: |
| 目的：比较维族与汉族乳腺癌患者的临床病理信息，旨在了解两民族之间乳腺癌临床病理特征的差异。方法：收集汉族病
例407 例，维族病例250 例，对临床病理资料、，应用免疫组化En Vision 两步法检测ER、PR、Her-2、BRCA1 进行对比分析。结果：
汉族及维族乳腺癌患者的年龄、淋巴结转移情况无统计学差异（P ＞ 0.05），汉族及维族患者乳腺癌的肿瘤大小、肿瘤组织学分级、
ER、PR、Her-2 及BRCA1 的表达有统计学差异（P＜0.05），维汉民族间三阴性乳腺癌的比例有显著统计学差异（P=0.0000）。维汉民
族三阴性乳腺癌与BRCA1 的表达存在相关性。结论：维汉民族间乳腺癌的临床病理特征存在差异，维族患者三阴性乳腺癌明显
多于患者患者，维汉民族患者三阴性乳腺癌均与BRCA1 基因突变有关。 |
| 英文摘要: |
| Objective:To compare the clinical features, histological grade of the Xinjiang Uygur and Han women with breast cancer,
in order to know the clinical and histological features of breast cancer between two nations.Methods:Four hundred and seven cases
of Han patients, 250 cases of Uighur patients were included in this study, the clinical and pathological data, histological grade, immunohistochemical
indicators ER, PR, Her-2, BRCA1were analyzed.Results:Ages, tumor sizes, lymph node metastasis of Han and Uygur of
breast cancer patients were no significant difference (P>0.05). Histological grade, estrogen receptor ER expression, and progesterone receptor,
Her-2, BRCA1receptor expression, triple negative breast cancer differences were significant different respectively (P＜0.05).Conclusion:There are differences between two nations of the clinical and histological features, Uygur of breast cancer pa- tients maybe
have the poor prognostic than Han patients. |
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