| 周逢海 吕海迪 郭秀全 王养民 宋灵敏.双氯芬酸钠栓和索利那新片治疗TURP 术后OAB的临床疗效观察[J].现代生物医学进展英文版,2014,14(25):4873-4876. |
| 双氯芬酸钠栓和索利那新片治疗TURP 术后OAB的临床疗效观察 |
| Observation on the Clinial Efficacy of Solifenacin and Diclofenac SodiumSuppositories in the Treatment of Overactive Bladder Syndrome afterTransurethral Resection of the Prostate |
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| DOI： |
| 中文关键词: 前列腺电切术 膀胱过度活动症 索利那新 双氯芬酸钠栓 |
| 英文关键词: TURP OAB Solifenacin Diclofenac SodiumSuppositories |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨双氯芬酸钠栓和索利那新治疗TURP术后OAB 的临床疗效及预防性用药的必要性。方法：采取随机区组单盲的
临床试验设计，将入选患者随机分为预防用药组和观察用药组。预防性用药组分别别使用双氯芬酸钠栓、索利那新片单药处理及
两种药物联合处理，观察用药组在出现症状后按照预防性用药组的相同方法给药。结果：观察用药组中，双氯芬酸钠栓治疗的完
全缓解率为50%，索利那新为81.8%，联合用药为90.5%，显著高于双氯芬酸钠栓(P<0.05)，各组不良反应的发生情况比较无显著
性差异(P>0.05)。预防用药组中，索利那新、双氯芬酸钠栓及联合用药分别可使TURP 术后OAB 的发生率降低45.0%、50.9%、
53.8%.，三组之间比较无统计学差异(P>0.05)，且三组不良反应的发生情况比较无显著性差异(P>0.05)。结论：双氯芬酸钠栓和索利
那新治疗TURP 术后OAB 均安全有效，联合用药效果更佳，且预防性用药可以显著降低TURP 术后OAB症状的发生率。 |
| 英文摘要: |
| Objective:To evaluate the effect of Solifenacin and Diclofenac Sodium Suppositories in the treatment of overactive
Bladder after transurethral resection of prostate, and assess the necessity of prophylactic treatment.Methods:All patients were divided
into 6 groups by randomized block design including combined drug group, the first three groups were prophylactic group, the other three
groups were observation treatment group. The prophylactic groups and observation treatment group both included Solifenacin group,
Diclofenac Sodium Suppositories, and combined drug group. In the prophylactic groups, drug was given to patients within 6-8h after
surgery, while in the observation treatment group, drug was given to the patients when OAB occurred.Results:In the observation
treatment group, the complete remission rate of solifenacin group, Diclofenac Sodium Suppositories, and combined drug group were
respectively 50%, 81.8%and 90.5%, which was the highest in the combined drug group (P<0.05); no significant difference was observed
in the incidence of adverse reactions among 3 groups (P>0.05). In the prophylactic group, 45.0%, 50.9%, 53.8%OAB after TURP were
prevented compared with the observation treatment groups, but no significant difference was observed among 3 groups (P>0.05).Conclusion:Solifenacin and Diclofenac Sodium suppositories were both effective in the treatment of OAB after TURP, combined
treatment was more effective, and prophylactic therapy could effectively decrease the incindence rate of OAB after TURP. |
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