| 赵帅 李家宁 丛莹莹 陈国萍 张艳玉.吸入乙酰半胱氨酸对博莱霉素导致的大鼠肺纤维化的影响[J].现代生物医学进展英文版,2014,14(25):4832-4836. |
| 吸入乙酰半胱氨酸对博莱霉素导致的大鼠肺纤维化的影响 |
| The Effect of N-acetylcysteine in Mucolytic Treatment on the BleomycinInduced Pulmonary Fibrosis in Rats |
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| DOI： |
| 中文关键词: N-乙酰半胱氨酸 大鼠肺纤维化 博莱霉素 |
| 英文关键词: N-acetylcysteine Pulmonary fibrosis in rats BLM |
| 基金项目:黑龙江省教育厅一般项目（11521096） |
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| 中文摘要: |
| 目的：研究N-乙酰半胱氨酸（NAC）雾化吸入对于博莱霉素（BLM）导致的大鼠肺纤维化的影响作用。方法：取清洁SD 大鼠
100 只，平均分为10 小组，1 小组为对照组，其余每3 小组为一组，分别为模型组，防治组，治疗组，通过在大鼠气管中注入BLM
的方法来制造大鼠肺纤维化模型，防治组在造模前的7 天以及造模后的7 天内，治疗组在造模后的7 天内,分别给予NAC 雾化吸
入治疗。在成功造模后的第7 天、14 天、28 天，每组处死1 小组大鼠，取出病理组织，通过免疫组化方法来观察肺组织纤维化的程
度。研究NAC对大鼠肺纤维化的影响。结果：与模型组对比，防治组和治疗组在纤维化程度上明显较轻（P<0.05）。结论：吸入NAC
对于博莱霉素导致的大鼠肺纤维化有明显的抑制作用，而且防治组疗效明显好于治疗组。既提前7 天用药，效果更明显，大鼠获
益更多。 |
| 英文摘要: |
| Objective:To study the projective effect of of N-acetylcysteine in mucolytic treatment on the bleomycin induced
pulmonary fibrosis in rats.Methods:The pulmonary fibrosis was induced by intratracheal instillation of bleomycin in rats. 100 rats were
involved and divided into 10 groups. One of the 10 groups was the normal control group, the other 9 groups were divided into the BLM
group, the preventing group and the treatment group with 3 branches in each group. The rats in the preventing group were trated by the
N-acetylcysteine for 7 days before molding. The rats in the treatment group were treated by tthe N-acetylcysteine for 7 days after
molding. 10rats of each group were sacrificed after using of bleomycin on days 7, 14, 28. The lungs were taken for histological study. The
immunity histochemical method was taken to observe the fibrosis degree.Results:The degrees of pulmonary fibrosis in the preventing
group and treating group were obviously reduced than the BLMgroup(P＜0.05).Conclusion:The effect of N-acetylcysteine in mucolytic
treatment on the bleomycin induced pulmonary fibrosis in rats was obviously,the curative effect in preventing group was better than
treating group.Using N-acetylcysteine 7days before molding,rats benefit more. |
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