| 谢蓓蓓 苏厚恒 李光文 马红 邢倩.痛风性关节炎与骨关节炎的相关性研究[J].现代生物医学进展英文版,2014,14(24):4727-4730. |
| 痛风性关节炎与骨关节炎的相关性研究 |
| Research on the Correlation of Gouty Arthritis with Osteoarthritis |
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| DOI： |
| 中文关键词: 痛风性骨关节炎 骨关节炎 Ⅱ型胶原羧基端端肽 单钠尿酸盐 |
| 英文关键词: Gouty arthritis Osteoarthritis C-telopeptide of type II collagen (CTX-II) Monosodiumurate |
| 基金项目: |
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| 中文摘要: |
| 目的：通过检测痛风性关节炎与骨关节炎患者膝关节液中Ⅱ型胶原羧基端端肽(C-telopeptide of type II collagen，CTX-Ⅱ)的
含量，探讨痛风性关节炎与骨关节炎的相关性。方法：收集膝关节发作的痛风性关节炎患者膝关节液标本46 例及骨关节炎患者
膝关节液标本42 例，用酶联免疫吸附试验(ELISA)法检测两组关节液中CTX-Ⅱ的含量，并研究分析痛风性关节炎膝关节液中
CTX-Ⅱ的含量与影像学X 线特征、单钠尿酸盐(MSU)晶体的相关性。结果：①痛风性关节炎与骨关节炎的膝关节液中CTX-Ⅱ的
含量相比较无统计学差异(P=0.40)；②45.7%(21/46)的痛风性关节炎患者膝关节X线显示骨关节炎，与膝关节X 线未显示骨关节
炎的痛风性关节炎(25/46)相比较，两组CTX-Ⅱ的含量无统计学差异(P=0.84 )；③MSU 晶体阳性的痛风性关节炎(19/46，41.3%)与
MSU晶体阴性的痛风性关节炎(37/46，68.7%)患者的膝关节液CTX-Ⅱ的含量比较，前者显著高于后者，差异有统计学意义(P＜
0.05)。结论：痛风性关节炎的受累关节存在关节软骨的退变，单钠尿酸盐(MSU)晶体在局部沉积与否与关节软骨退变的程度相关。 |
| 英文摘要: |
| Objective:To explore the correlation of gouty arthritis with osteoarthritis through determining the content of
C-telopeptide of type II collagen (CTX-II) in the synovial fluid.Methods:A group of 46 patients with gouty arthritis and a group of 42
patients with osteoarthritis were included in the study. The synovial fluid from all patients was obtained through keen joint puncturing.
The content of CTX-II in the synovial fluid was determined by Enzyme-linked immunosorbent assay (ELISA). Further to analyze the
correlation of the content of CTX-II in the synovial fluid from gouty arthritis patients with X-ray features of gouty arthritis and
monosodiumurate (MSU) crystals.Results:There was no statistical difference in the content of CTX-II between gouty arthritis group and
osteoarthritis group (P=0.40); 45.7% (21/46) of gouty arthritis showed X-ray knee osteoarthritis. Comparing with gouty arthritis with
negative X-ray knee osteoarthritis (25/46), there was no statistical difference between the two groups (P= 0.84); MSU crystals were
observed in 41.3% (19/46) of gouty arthritis under a polarization microscope. Comparing with gouty arthritis of negative MSU crystal.
The content of CTX-II in the former was significantly higher than that in the latter. There was significant difference in the content of
CTX-II between the two groups (P<0.05).Conclusion:The joint attacked by gouty arthritis occurs cartilage degeneration and whether
MSU crystals locally deposit is associated with the degree of cartilage degeneration. |
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