| 杜凯音 徐洪涛 张宝和 李静 康怡 胡晓东 王吉 孙洪良 连士杰 华伟 王铁燕 郭晓东.健康查体人群非酒精性脂肪肝发病的相关危险因素分析[J].现代生物医学进展英文版,2014,14(24):4714-4718. |
| 健康查体人群非酒精性脂肪肝发病的相关危险因素分析 |
| Analysis of Risk Factors of Nonalcoholic Fatty Liver Diseasein People Undergoing Physical Examination |
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| DOI： |
| 中文关键词: 非酒精性脂肪性肝病 危险因素 Logistic 回归分析 |
| 英文关键词: Nonalcoholic fatty liver disease Risk factors Logistic regression analysis |
| 基金项目:海军后勤部科研课题（CHJ12L024） |
| Author Name | Affiliation | | DU Kai-yin,XU Hong-tao, ZHAN Bao-he, LI Jing, KANG Yi,HU Xiao-dong, WANG Ji, SUN Hong-liang, LIANG Shi-jie, HUA Wei, WANG Tie-yan, GUO Xiao-dong | 海军总医院干部保健科；北京同仁医院；
海军机关门诊部；解放军第302 医院 |
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| 中文摘要: |
| 目的：探讨非酒精性单纯性脂肪肝以及由其演变的脂肪性肝炎各指标的差异，并分析非酒精性脂肪肝病（Nonalcoholic Fatty
Liver Disease, NAFLD）的相关影响因素，为NAFLD 防治提供依据。方法：入选病例分为正常组（A组，n=189）、单纯性脂肪肝组（B
组，n=162）、脂肪肝伴肝功能改变组（C 组，n=23），分析其体检结果及生活方式等影响因素，应用单因素及Logistic 回归分析进行
统计学处理。结果：C 组大多数各项指标均比B 组有所升高，其中体质量指数（BMI）、丙氨酸转氨酶（ALT）、低密度脂蛋白胆固醇
（LDL-C）、尿素氮（BUN）、空腹胰岛素（FIns）、餐后2 小时胰岛素（2h PIns）差异有统计学意义(P＜0.05)。在B组和C 组中ALT、高
密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、Fins、2hPIns、腰臀比（WHR）与A 组比较均有显著差异(P＜0.05)；男性NAFLD 的发
病率比女性高，差异有统计学意义(x2=6.86，P＜0.05)。有高脂血症组单纯性脂肪肝发病率高于没有高脂血症组，差异有统计学意义(x2=26.11，P＜0.05)。有高血压病史的NAFLD 发病率比无高血压病史的高，差异显著(x2=7.39，P＜0.05)；Logistic 回归分析显示，
BMI、TC、HbA1c、有高血压病史是NAFLD 的危险因素。结论：NAFLD 与代谢综合征密切相关，NAFLD 中伴肝功异常组存在更明
显的胰岛素抵抗、血脂紊乱现象，更易于患慢性肾脏疾病。 |
| 英文摘要: |
| Objective:To investigate the differences of markers between nonalcoholic simple fatty liver (NAFL) and nonalcoholic
steatohepatitis (NASH) in people who were taking the physical examination, and to analyze the risk factors of nonalcoholic fatty liver
disease (NAFLD) so as to provide an evidence for NAFLD treatment.Methods:The cases were classified into groupA (control group,
n=189), group B (NAFL, n=162) and groupC (NASH, n=23). The physical examination results and life style were analyzed. The
univariate analysis and Logistic regression analysis was applied.Results:Most of the makers in group C were higher than that in group B.
BMI, ALT, LDL-C, BUN, Fins and 2hPIns showed significant differences (P<0.05). HDL-C, TG, Fins, 2hPIns and WHR in group B and
C were higher than that in groupA (P<0.05). The incidence of NAFLD was higher in male patients than female ones (X2=6.86, P<0.05).
The prevalence of hypertension and hyperlipemia in NAFLD group was higher than that of control group (X2=26.11, P<0.05; X2=7.39,
P<0.05). Logistic regression analysis revealed that BMI, TC, HbA1c and history of hypertension were the risk factors of NAFLD.Conclusion:NAFLD is closely associated with the metabolic syndrome and NASH group has more obvious phenomenon of dyslipidemia
of insulin resistance and easier to suffer fromchronic kidney disease than other groups. |
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